Rabbit anti-AFP Recombinant Mo

别名：兔抗AFP重组单克隆抗体(R077)

免疫原：见优宁维官网

应用：WB: 1:500-1:1000, IP: 1:25, IHC-P: 1:1000, ICC: 1:100-1:200

保持条件：Store at -20℃ for one year.

使用方法：WB,IP,IHC-P,ICC

标记：Unlabeled

宿主：Rabbit

反应种属：见优宁维官网

克隆性：R077

产品描述：

Alpha-fetoprotein (AFP) is a 65 kDa glycoprotein found in the serum of the mammalian fetal liver, yolk sac, and GI tract. While AFP expression in adult cells is low, it is aberrantly expressed in adult liver cancer cells (1,2). The tumor suppressor gene p53 and β-catenin are both involved in the regulation of AFP expression. In normal adult cells, p53 binds to the repressor region of the AFP gene, thereby blocking transcription. Mutations in both p53 and β-catenin are associated with aberrant expression of AFP. Elevated serum levels are predictive of hepatocellular carcinoma (3).

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