Rabbit anti-Smad4 Recombinant

别名：兔抗Smad4重组单克隆抗体(168-67)

免疫原：Synthetic Peptide

应用：WB: 1:1000, IP: 1:50

保持条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

使用方法：WB

标记：Unlabeled

宿主：Rabbit

反应种属：见优宁维官网

克隆性：168-67

产品描述：

This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

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