Rabbit anti-TPSAB1 Recombinant

别名：兔抗TPSAB1重组单克隆抗体(R038)

免疫原：见优宁维官网

应用：IHC-P: 1:1000

保持条件：Store at -20℃ for one year.

使用方法：IHC-P

标记：Unlabeled

宿主：Rabbit

反应种属：见优宁维官网

克隆性：R038

产品描述：

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3‘ UTR and contain tandem repeat sequences at the 5‘ flank and 3‘ UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.

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