K117561P Anti-CGAS Polyclonal

Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2’，3’-cGAMP) from ATP and GTP and plays a key role in innate immunity.Catalysis involves both the formation of a 2’，5’ phosphodiester linkage at the GpA step and the formation of a 3’，5’ phosphodiester linkage at the ApG step， producing c[G(2’，5’)pA(3’，5’)p].Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA)， inducing the formation of liquid-like droplets in which CGAS is activated， leading to synthesis of 2’，3’-cGAMP， a second messenger that binds to and activates STING1， thereby triggering type-I interferon production.Acts as a key foreign DNA sensor， the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses.Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm.Also acts as an innate immune sensor of infection by retroviruses， such as HIV-2， by detecting the presence of reverse-transcribed DNA in the cytosol.