- ￥2950 - 4850
- Solarbio|ActivAb
- 北京
- K011389M
- 2025年08月19日
- WB;ELISA
- Rabbit
- Human;Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
A synthetic peptide of human Phospho-NF-κB p65 (Ser468)
- 亚型：
IgG
- 保存条件：
Store at -20℃. Avoid freeze / thaw cycles.
- 克隆性：
Monoclonal Antibody
- 标记物：
Biotin，Cy3，Cy3.5，Cy5，Cy5.5，Cy7，FITC，HRP，RBITC，Solar Fluor 350，Solar Fluor 405，Solar Fluor 488，Solar Fluor 532，Solar Fluor 555，Solar Fluor 568，Solar Fluor 594，Solar Fluor 633，Solar Fluor 640，Solar Fluor 647，Solar Fluor 660，Solar Fluor 680，Solar Fluor 750
- 适应物种：
Human;Mouse
- 抗原来源：
A synthetic peptide of human Phospho-NF-κB p65 (Ser468)
- 目录编号：
5970
- 级别：
实验级别
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 应用范围：
WB;ELISA
- 浓度：
WB 1:2000-10000.
- 靶点：
Phospho-NF-κB p65 (Ser468)
- 抗体英文名：
Anti-Phospho-NF-κB p65 (Ser468) Monoclonal Antibody
- 抗体名：
磷酸化细胞核因子NF-κB p65抗体
- 规格：
50ul/100ul
| 规格： | 50ul | 产品价格： | ￥2950.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥4850.0 |
| 基本信息 | |
| 英文名称 | Anti-Phospho-NF-κB p65 (Ser468) Monoclonal Antibody |
| 中文名称 | 磷酸化细胞核因子NF-κB p65抗体 |
| 宿主 | Rabbit |
| 克隆类型 | Monoclonal Antibody |
| 亚型 | IgG |
| 交叉反应 | Human;Mouse |
| 应用 | WB;ELISA |
| 稀释比例 | WB 1:2000-10000. |
| 密度 | |
| 靶标 | Phospho-NF-κB p65 (Ser468) |
| 别名 | NF kB P65,NF-kB p65,NF-kB-p65,NFKBp65,NF-κBp65,NF-kBp65,Avian reticuloendotheliosis viral (v rel) oncogene homolog A,MGC131774,NFKB 3,NFKB3,RELA |
| 背景说明 | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Beside its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. |
| Swiss Prot | Q04206 |
| Gene ID | 5970 |
| 亚细胞定位 | Cytoplasm Nucleus |
| 免疫原 | A synthetic peptide of human Phospho-NF-κB p65 (Ser468) |
| 理论分子量 | 65kDa |
| 实际分子量 | 75kDa |
| EC | |
| 纯化方法 | Affinity purification |
| 储存液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| 储存条件 | Store at -20℃. Avoid freeze / thaw cycles. |
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文献和实验antibody dilution buffer: TBS-T supplemented with2% (w/v) BSA. 6. Antibodies: Phospho-b-catenin Ser33/Ser37/Thr41, phospho-glycogen synthase Ser641, and glycogen synthase (CellSignaling Technologies, Beverly, MA); b-catenin and GSK-3b(BD PharMingen, San
v468. chapter 4 WNT 细胞通路 检测细胞GSK3活性与表达水平
are prepared using Adobe Photoshop and MicrosoftPowerpoint software. 2.5. Immunoprecipitation Kinase Activity Assays 1. The anti-GSK3b monoclonal antibody is from BD TransductionLaboratories (#610201) and protein G-Sepharose is fromAmersham (#17-0618-01
三叶虫 大家好，我最近准备做NF-κB信号通路中的P65，P50还有IKK，IκB。请问各位买哪个公司的抗体好，中衫的怎样？ 望各位多多指教。谢谢！！ 三叶虫 顶自己一下。。 siru1234 你好，建议你买大品牌的抗体，质量有保证，我以前就曾用过abcom和sigma 的抗体，挺好用的。我们公司专门做血清的，如果你有需要可以联系，QQ：1137173658，电话：021
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