(4-Fluorophenyl)-4-oxo-1,4-dih

Molecular Modeling of Nucleic Acid Structure: Electrostatics and Solvation

of computer simulation techniques as applied to nucleic acid systems, ranging from simple in vacuo molecular modeling techniques to more complete all?atom molecular dynamics treatments that include an explicit representation of the environment. The third in a series

一文读懂国自然科研热点：外泌体

最近，娱乐界有两部宫廷剧比较火，估计大家都略有耳闻，那便是《延禧攻略》和《如懿传》。其实在我们科研界，最近也有个比较火的“明星”，它就是外泌体（Exosomes）。 那么到底什么是外泌体？它又有哪些特征及作用呢？如何研究外泌体呢？接下来我们将一一为大家解答。 一、什么是外泌体？ 外泌体是由细胞分泌的直径为 30~150 nm 的小囊泡，内含来源于细胞相关的蛋白质与核苷酸等生物分子，在细胞交流间起重要作用。具有减少细胞凋亡、减轻炎症反应、促进血管

Molecular Modeling of Nucleic Acid Structure: Energy and Sampling

techniques as applied to nucleic acid systems is presented. This unit discusses methods used to treat energy and to sample representative configurations. Emphasis is placed on molecular mechanics and empirical force fields. Curr. Protoc. Nucleic Acid Chem