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- 文献和实验
- 技术资料
- 抗体名：
Alexa Fluor® 488 anti-mouse/rat/human FOXP3
- 抗体英文名：
Alexa Fluor® 488 anti-mouse/rat/human FOXP3
- 供应商：
上海善然生物科技有限公司
- 保存条件：
2-8℃
- 规格：
100tests
Alexa Fluor® 488 anti-mouse/rat/human FOXP3 Antibody
150D
Catalog# / Size
320012 / 100 tests
Clone
Regulatory Status RUO
Other Names Forkhead box protein P3, Scurfin, JM2, IPEX, Zinc finger protein JM2
Isotype Mouse IgG1, κ
Description FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2,
or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory
cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3
in CD4 /CD25 cells has been shown to induce GITR, CD103, and CTLA4 and impart a T
regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation
syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been
shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central
regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported:
one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking
exon 2. The 150D monoclonal antibody reacts with human, mouse and rat FOXP3. The 150D
antibody recognizes FOXP3 epitope encoded by exon 2.
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文献和实验® 555 Conjugate）#4409 Anti-Mouse IgG（H+L）， F（ab'）2 Fragment（Alexa Fluor® 647 Conjugate）#4410 抗大鼠： Anti-Rat IgG（H+L），（Alexa Fluor® 488 Conjugate）#4416 Anti-Rat IgG（H+L），（Alexa Fluor® 555 Conjugate）#4417 Anti-Rat IgG（H+L），（Alexa
偶联物，最大限度的提高了信噪比。图2. CF染料的超强特异性；由于AF染料制备过程中含有大量带负电的磺化基团，容易非特异性结合正电基团，请看AF790 Dye与CF790的条带特异性对比。3. 优异的标记效率生物偶联后的活性染料一般很容易水解，会在运输，操作及储存中带来诸多不便，最终致染料结合效率低下。像Alexa Fluor® dyes,DyLight? dyes and IRDyes®等严重的磺化作用有较强的吸湿性，恶化水解作用等问题。例如： AlexaFluor® 488 在应用时琥珀酰亚胺脂酯
：Catalog NumberProduct NameProduct TypeSizeApplication4408SAnti-mouse IgG (H+L), F(ab')2 Fragment (Alexa Fluor® 488 Conjugate)Secondary Antibody250µlIF-IC F HCA4409SAnti-mouse IgG (H+L), F(ab')2 Fragment (Alexa Fluor® 555 Conjugate)Secondary
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