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Anti-Ryanodine Receptor 2 / RY

R2 Recombinant Rabbit Monoclonal Ab
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  • ¥860
  • Elucigen Biosciences
  • ERB0560
  • 2025年08月13日
  • IHC, WB
  • Rabbit
  • Human
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  • 企业认证

    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      Synthetic peptide corresponding to the internal region of human RYR2.

    • 亚型

      IgG

    • 形态

      Liquid

    • 保存条件

      -20°C

    • 克隆性

      Monoclonal

    • 标记物

      Unconjugated

    • 适应物种

      Human

    • 保质期

      12 months from the shipping date of the product.

    • 抗原来源

      Human

    • 目录编号

      ERB0560

    • 级别

      Primary Antibodies

    • 库存

      Available

    • 供应商

      Elucigen Biosciences

    • 宿主

      Rabbit

    • 应用范围

      IHC, WB

    • 浓度

      0.5 mg/mL

    • 靶点

      Q92736

    • 抗体英文名

      Anti-Ryanodine Receptor 2 / RYR2 Recombinant Rabbit Monoclonal Ab

    • 抗体名

      Anti-Ryanodine Receptor 2 / RYR2 Recombinant Rabbit Monoclonal Ab

    • 规格

      25μg/100μg/500μg

    规格:25μg产品价格:¥860.0
    规格:100μg产品价格:询价
    规格:500μg产品价格:询价
    RYR2 is a gene that encodes the ryanodine receptor 2, a large intracellular calcium release channel primarily expressed in cardiac muscle. Located on the membrane of the sarcoplasmic reticulum (SR), RYR2 plays a critical role in excitation–contraction coupling, the process by which an electrical signal triggers heart muscle contraction. When cardiac muscle is stimulated, a small influx of calcium through L-type calcium channels on the cell membrane activates RYR2 to release a much larger amount of calcium from the SR into the cytoplasm—a process known as calcium-induced calcium release (CICR). This surge in calcium binds to troponin and initiates cardiac muscle contraction. RYR2 is essential for maintaining proper heart rhythm and contractility, and mutations in the RYR2 gene are linked to cardiac arrhythmias, including catecholaminergic polymorphic ventricular tachycardia (CPVT) and arrhythmogenic right ventricular cardiomyopathy (ARVC). It is also studied in the context of heart failure, sudden cardiac death, and calcium signaling disorders. Given its vital role in calcium homeostasis and heart function, RYR2 is a major focus in cardiovascular research, as well as in the development of anti-arrhythmic therapies.

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    图标文献和实验
    该产品被引用文献
    Lanner, JT., et al. (2010). Cold Spring Harb. Perspect. Biol. 2(11); a003996
    相关实验
    • Indirect Immunofluorescence

      Reagents:  NGS-Normal Goat Serum  PBST-0.5% Tween-20/CMF-PBS  CMF-PBS  1°Ab-mouse MF20 (anti-myosin monoclonal)  1°Ab-rabbit myoD (anti-myoD polyclonal)  2°Ab-goat anti-mouse IgG-FITC  2°Ab-goat anti-rabbit IgG-FITC

    • ELISA PROTOCOL 【Yale University 】

      -nitrophenyl phosphate (5 mg/tablet). SigmaCat.# N93895) AP-conjugated secondary Ab: AP-Rabbit anti-mouse IgG(Zymed). Reconstitute in ddH2O as prescribed by manufacturer andaliquot and store at -70 °C.6) 100 mM EDTA pH

    • Staining for total receptors

      , and apply primary Ab only to the coverslip. Incubate 45'. Dilute antibody with Blotto. Some typical dilutions are listed below: monoclonal M1 mouse anti-Flag antibody (Sigma , Covance ) (Ca+2 sensitive) 1:350-1:500; polyclonal 12CA5 mouse anti-HA (Roche

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    文献支持
    Anti-Ryanodine Receptor 2 / RYR2 Recombinant Rabbit Monoclonal Ab
    ¥860