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- Sigma-Aldrich
- 进口
- S9763-100G
- 2025年08月13日
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- 保存条件：
常温
- 保质期：
根据瓶身LOT号查询
- 英文名：
Sodium phosphate dibasic
- 库存：
有现货
- 供应商：
浙江羽翔生物科技有限公司
- CAS号：
7558-79-4
- 规格：
100G
属性
等级
ACS reagent
质量水平
200
Agency
suitable for SM 5210
方案
≥99.0%
表单
powder
杂质
≤0.002% Chloride (Cl)
≤0.01% Insoluble matter
缺失
≤0.2% loss on drying, 105°C
pH值（酸碱度）
8.7-9.3 (25 °C, 5% in solution)
pKa (25 °C)
(1) 2.15, (2) 6.82, (3) 12.38 (phosphoric acid)
溶解性
water: 5% at 25 °C, clear
痕量阴离子
sulfate (SO42-): ≤0.005%
痕量阳离子
Fe: ≤0.002%
heavy metals: ≤0.001% (by ICP-OES)
SMILES字符串
[Na+].[Na+].[H]OP([O-])([O-])=O
InChI
1S/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-2
InChI key
BNIILDVGGAEEIG-UHFFFAOYSA-L
一般描述
应用
- 制备用于灌注的磷酸盐缓冲液
- 蛋白免疫印迹分析
- 间接酶联免疫吸附测定
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文献和实验Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma.
To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic opportunities, we performed comprehensive proteogenomic characterization of 110 tumors and 101 matched normal adjacent tissues (NATs) incorporating genomics, epigenomics, deep-scale proteomics, phosphoproteomics, and acetylproteomics. Multi-omics clustering revealed four subgroups defined by key driver mutations, country, and gender. Proteomic and phosphoproteomic data illuminated biology downstream of copy number aberrations, somatic mutations, and fusions and identified therapeutic vulnerabilities associated with driver events involving KRAS, EGFR, and ALK. Immune subtyping revealed a complex landscape, reinforced the association of STK11 with immune-cold behavior, and underscored a potential immunosuppressive role of neutrophil degranulation. Smoking-associated LUADs showed correlation with other environmental exposure signatures and a field effect in NATs. Matched NATs allowed identification of differentially expressed proteins with potential diagnostic and therapeutic utility. This proteogenomics dataset represents a unique public resource for researchers and clinicians seeking to better understand and treat lung adenocarcinomas.
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大肠杆菌亮氨酰-tRNA合成酶E292对于氨基酰化活性的作用
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