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- 美国
- 2026年05月29日
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- 文献和实验
- 技术资料
- 抗体名：
Spark Violet™ 538 anti-human CD45
- 抗体英文名：
Spark Violet™ 538 anti-human CD45
- 供应商：
上海善然生物科技有限公司
- 保存条件：
2-8℃
- 规格：
100tests
Spark Violet™ 538 anti-human CD45 Antibody
HI30
Catalog# / Size
304082 / 100 tests
Clone
Regulatory Status RUO
Workshop IV N816
Other Names LCA, T200
Isotype Mouse IgG1, κ
Description CD45 is a 180-240 kD single chain type I membrane glycoprotein also known as leukocyte
common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma
membrane of all hematopoietic cells, except erythrocytes and platelets. CD45 is a signaling
molecule that regulates a variety of cellular processes including cell growth, differentiation, cell
cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen
receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and
other Src family kinases. CD45 non-covalently associates with lymphocyte phosphataseassociated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind
galectin-1 and to be associated with several other cell surface antigens including CD1, CD2,
CD3, and CD4.
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悬液的表型鉴定和功能分析。巨噬细胞没有类似于T细胞（CD4/CD8）那样明确的单一区分抗原，因此需要使用一组标志物的组合来鉴定巨噬细胞。对于小鼠巨噬细胞，常用的组合包括F4/80、CD11b、Ly6C和THY-1等。通过多色荧光标记和流式细胞仪分析，可以在异质性细胞群中精确地鉴定和分选出巨噬细胞。 图5. C57BL/6J腹腔炎症小鼠取腹水样本，使用PE Anti-Mouse/Human/Monkey CD11b Antibody[M1/70]（E-AB-F1081D）、Elab Fluor®
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