(2S,4R)-4-Amino-2-methyl-piper

Synthesis of (2R, 3R, 4R, 5S)-5-tert-Butyloxycarbonylamino-3,4-Dihydroxy-2-1sopropyl-3,4-O,O-Isopropylidene-6-CyctohexyI-Hexanoic Acid

The dipeptidic dihydroxyethylene isostere (27, 3R , 4R , 5S )-5-tert -butyloxy-carbonylamino-3,4-dihydroxy-2-isopropyl-3,4-O,O -isoprop-ylidene-6-cyclohexyl-hexanoic acid, 15 , is a representative building block of an important class

Enzymes Acting on d-Amino Acid Containing Peptides

aminopeptidase and endopeptidase activities. The enzyme was active toward (d -Phe) n , Boc-(d -Phe) n , (d -Phe) n methyl ester, d -Phe-NH2 , Boc-(d -Phe) n methyl ester, and Boc-(d -Phe) n tert -butyl ester, but not toward (d -Ala) n (n = 2–4), (d

Biotinylation of a Propargylated Cyclic (3′‐5′) Diguanylic Acid and of Its Mono‐6‐Thioated Analog Under “Click” Conditions

?isobutyryl?5??O ?(4,4??dimethoxytrityl)?2??O ?(propargyl)guanosine is converted to its 3??O ?levulinyl ester in a yield of 91%. The reaction of commercial N 2 ?isobutyryl?5??O ?(4,4??dimethoxytrityl)?2??O ?tert ?butyldimethylsilyl?3??O ?[(2?cyanoethyl)?N ,N