(oxiran-2-ylmethoxy)-1,2,3,4-

A Conformationally Restricted -Strand HIV Protease Inhibitor

after the potent HIV protease inhibitor 2 , which together with a series of related derivatives was developed at Abbott Laboratories ( 11 ). This pseudopeptide contains a symmetrical diamino diol motif 8 (Fig. 2 ) flanked by Cbz-protected valine residues

Synthesis of Building Blocks and Oligonucleotides with {G}O6‐Alkyl‐O6{G} Cross‐Links

as a protected diol using two successive Mitsunobu reactions to produce a cross?linked amidite that is incorporated into an oligonucleotide via solid?phase synthesis. The use of a protected diol lends versatility to this method, as cross?links of variable chain

L1和L8是什么类型的柱子?它是怎么规定的？

离子交换柱 L7：全多孔硅胶微粒键合C8官能团固定相，简称C8柱 L8：全多孔硅胶微粒键合非交联NH2固定相，简称NH2柱 L9：强酸性阳离子交换基团键合全多孔不规则形硅胶固定相，即SCX柱 L10：多孔硅胶微球键合氰基固定相（CN），简称CN柱 L11：键合苯基多孔硅胶微球固定相，简称苯基柱 L12：无孔微球键合季胺功能团的强阴离子交换柱 L13：三乙基硅烷化学键合全多孔硅胶微球固定相（C1），简称C1柱 L14：10mm硅胶化学键合强碱性季铵