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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
Store at -20℃,2 years.(Avoid freeze/thaw cycles)
- 保质期:
Store at -20℃,2 years.(Avoid freeze/thaw cycles)
- 英文名:
Amyloid Precursor Frameshift Mutant C-Terminal Peptide
- 库存:
现询
- 供应商:
北京索莱宝科技有限公司
- 规格:
10mg/5mg/1mg
| 规格: | 10mg | 产品价格: | ¥2170.0 |
|---|---|---|---|
| 规格: | 5mg | 产品价格: | ¥1550.0 |
| 规格: | 1mg | 产品价格: | ¥620.0 |
| 基本信息 | |
| 产品类型 | 多肽 |
| CAS | No.89430-38-6 |
| 单字母序列 | RPKPQQWFWWM-NH2 |
| 三字母序列 | Arg-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Trp-Met-NH2 |
| 分子式 | C79H105N21O13S1 |
| 分子量 | 1588.88 |
| 纯度 | ≥95% |
| 外观(性状) | 冻干粉;Lyophilized powder |
| 盐体系 | TFA盐;Trifluoroacetate salt |
| 来源 | 合成;Synthetic |
| 储存条件 | Store at -20℃,2 years.(Avoid freeze/thaw cycles) |
| 类别/标签 | 底物和酶抑制剂(Substrate and Enzyme Inhibitors) |
| 规格 | [D-Trp7,9,10]-Substance P 是 substance P 的类似物。Substance P 刺激 substance P 受体,但也通过CHN2乙酰胆碱受体抑制离子传导。 |
| In Vitro | Substance P (SP)-related peptide, pGlu-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2, inhibitS the activation of Gi or Go by M2 muscarinic cholinergic receptor (M2 mAChR) or of Gs by beta-adrenergic receptor in the reconstituted phospholipid vesicles, assayed by receptor-promoted GTP hydrolysis. |
| 单位 | 瓶 |
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文献和实验病理特征的动物模型。关键词:Alzheimer 病;动物模型;β-淀粉样肽;脑室Alzheimer 病(AD) 是包括遗传因素、慢性感染、免疫缺陷和环境毒素等多种原因引起的神经退行性疾病,其病理特征主要表现为老年斑、神经纤维缠结和神经元丢失。研究显示,β-淀粉样肽(β-amyloid ,Aβ) 是AD发病的早期共同病理促发因素,能引起氧化应激反应的增加,导致AD脑中胆碱能系统功能降低,激活糖原合酶激酶3(Glycogen synthase kinase-3,GSK3β)和促进Tau蛋白的异常磷酸化,介导炎症
Determining the Transmembrane Topology of the Presenilins
in the endoplasmic reticulum and Golgi (4 -7 ). PS1 is a 467 amino acid peptide predicted to contain between seven and nine transmembrane helices based on hydrophobicity profiles (1 ,8 ). The protein topology of PS1 and its C. elegans homologues, SEL-12 and HOP
for analysis. This reduces the complexity of the peptide mixture before MS is performed and facilitates phosphopeptide identification (Fig. 14). Phosphopeptides can be identified from a mixture of peptides by a method known as precursor ion scanning (116
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