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- 详细信息
- 技术资料
- 保存条件:
Store at -20℃,2 years.(Avoid freeze/thaw cycles)
- 保质期:
Store at -20℃,2 years.(Avoid freeze/thaw cycles)
- 英文名:
ApoA-I mimetic peptide
- 库存:
现询
- 供应商:
北京索莱宝科技有限公司
- 规格:
10mg/5mg/1mg
| 规格: | 10mg | 产品价格: | ¥1960.0 |
|---|---|---|---|
| 规格: | 5mg | 产品价格: | ¥1400.0 |
| 规格: | 1mg | 产品价格: | ¥560.0 |
| 基本信息 | |
| 产品类型 | 多肽 |
| CAS | No.124932-61-2 |
| 单字母序列 | VNTPEHVVPYGLGSPRS |
| 三字母序列 | Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser |
| 分子式 | C80H125N23O25 |
| 分子量 | 1809.01 |
| 纯度 | ≥95% |
| 外观(性状) | 冻干粉;Lyophilized powder |
| 盐体系 | TFA盐;Trifluoroacetate salt |
| 来源 | 合成;Synthetic |
| 储存条件 | Store at -20℃,2 years.(Avoid freeze/thaw cycles) |
| 类别/标签 | 心血管研究(Cardiovascular research) |
| 规格 | Big Endothelin-1 (22-38), human 是由人源的大内皮素 1 (ET-1) 的 22-38 片段 (1-38);大内皮素 1 (1-38) 是 ET-1 的前肽,具有强大而持久的血管收缩作用,其 38 个氨基酸链发生特定的酶切,形成内皮素 1 (1-21) 和 C 端片段大内皮素 1 (22-38)。 Big Endothelin-1 (22-38), human is derived from human, is the 22-38 fragment of Big Endothelin-1 (ET-1) (1-38). Big ET-1 (1-38) is a propeptide of ET-1, which has potent and long-lasting vasoconstrictor effects, equips a specific enzymatic cleavage of the 38 amino acid chain to form ET-1 (1-21) and the C-terminal fragment Big ET-1 (22-38). |
| In Vitro | Big Endothelin-1 (22-38), human (0.1 μM; 30 min) induces the release of prostacyclin (PGI2) from rabbit, guinea pig, and rat lungs. |
| In Vivo | Big Endothelin-1 (22-38), human (3 nM/kg; intra-arterial injection; single dose) produces a significant rise in left ventricular systolic pressure (LVSP) in anesthetized rabbits, and is enhanced by cyclooxygenase inhibitor Indomethacin (HY-14397) (5 mg/kg i.v.) significantly. Big Endothelin-1 (22-38), human (3 nM/kg; intravascular method; single dose), has no antiaggregatory properties for platelet induced by ADP in rabbits. |
| 单位 | 瓶 |
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