- ￥560 - 1960
- Solarbio|ActivAb
- 北京
- CLP0076
- 2025年07月29日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20℃，2 years.(Avoid freeze/thaw cycles)
- 保质期：
Store at -20℃，2 years.(Avoid freeze/thaw cycles)
- 英文名：
MAGE-3 Antigen (271-279) (human)
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
10mg/5mg/1mg
| 规格： | 10mg | 产品价格： | ￥1960.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥1400.0 |
| 规格： | 1mg | 产品价格： | ￥560.0 |
| 基本信息 | |
| 产品类型 | 多肽 |
| CAS | No.197794-83-5 |
| 单字母序列 | TFLLR-NH2 |
| 三字母序列 | Thr-Phe-Leu-Leu-Arg-NH2 |
| 别名 | 血酶受体;(Thr1)-PAR-1 (1-5) amide (human);TFLLR-NH2 Protease-Activated Receptor 1 (PAR1) Agonist |
| 分子式 | C31H53N9O6 |
| 分子量 | 647.82 |
| 纯度 | ≥95% |
| 外观(性状) | 冻干粉;Lyophilized powder |
| 溶解性 | H2O：100 mg/mL; DMSO：100 mg/mL; *超声助溶; |
| 盐体系 | TFA盐;Trifluoroacetate salt |
| 来源 | 合成;Synthetic |
| 储存条件 | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| 类别/标签 | 蛋白激酶相关肽(Protein Kinase Related Peptides) |
| 规格 | TFLLR-NH2是选择性的PAR1激动剂，EC50值为1.9 μM。TFLLR-NH2 is a selective PAR1 agonist with an EC50 of 1.9 μM. |
| In Vitro | PAR1 agonists stimulate concentration-dependent increases in [Ca2+]i and in the proportions of neurones. The maximal increase in [Ca2+]i above basal is detected in response to 10 μm TF-NH2 (peak 196.5±20.4 nM, n=25) when 50–80% of identified neurones responded. SW620 cells cultured in the supernatant of TFLLR-NH2-activated platelets upregulate E-cadherin expression and downregulate the vimentin expression. In the in vitro platelet culture system, a TFLLR-NH2 dose-dependent increase of secreted TGF-β1 is detected in the supernatant. |
| In Vivo | Injection of TF-NH2 into the rat paw stimulates a marked and sustained oedema. An NK1R antagonist and ablation of sensory nerves with capsaicin inhibit oedema by 44% at 1 h and completely by 5 h. In wild-type but not PAR1 / mice, TF-NH2 stimulates Evans blue extravasation in the bladder, oesophagus, stomach, intestine and pancreas by 2–8 fold. Extravasation in the bladder, oesophagus and stomach is abolished by an NK1R antagonist. TFp-NH2 produces notable contraction at 3-50 μM and relaxation at 0.3-50 μM, in the absence of apamin. The concentration-response curve for TFp-NH2-induced contraction is remarkably shifted left, when the TFp-NH2-induced relaxation is blocked by apamin at 0.1 μM. |
| 单位 | 瓶 |
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文献和实验【分享】Human press METHODS IN MOLECULAR BIOLOGY
9. Protocols in Human Molecular Genetics. Edited by G. Methaw, 1991 10. Immunochemical Protocols. Edited by Manson, Margaret M., 1992 11. Practical Protein Chromatography Edited by Kenney, Andrew, 1992 12. Pulsed-Field Gel Electrophoresis Protocols
v468. chapter 4 WNT 细胞通路 检测细胞GSK3活性与表达水平
(7) . GSK3 is one of the most unusual kinases of the 500 or soencoded in the human genome. Firstly, most (if not all) substratesrequire prior phosphorylation by another kinase beforethey can be efficiently phosphorylated by GSK3. This process isknown
-1 : The murine IgM monoclonal Ab STRO-1, produced from an immunization with a population of human CD34+ bone marrow cells, can identify a cell surface antigen expressed by stromal elements in human bone marrow.55 From bone marrow cells, the frequency
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