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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
-20℃ to -80℃
- 保质期:
12个月
- 英文名:
Recombinant Human HER2 / ErbB2 Protein (His & AVI Tag), Biotinylated
- 库存:
99
- 供应商:
北京义翘神州科技股份有限公司
- 规格:
20.00 µg///100.00 µg
蛋白名称:Human HER2 / ErbB2 Protein (His & AVI Tag), Biotinylated, Endotoxin-Free
蛋白构建:A DNA sequence encoding the human ERBB2 (NP_004439.2) (Met1-Thr652) was expressed with a c-terminal polyhistidine tagged AVI tag at the C-terminus. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
表达宿主:HEK293 Cells
蛋白纯度:≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
蛋白内毒素:< 0.5 EU per mg protein.
预测N端:Thr 23
蛋白分子量:The recombinant human ERBB2 consists of 656 amino acids and predicts a molecular mass of 72.6 kDa.
蛋白NP号:NP_004439.2
蛋白氨基酸序列:Met1-Thr652
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文献和实验被切除,HSV―TK才得以表达。两个载体共感染将特异性地杀伤CEA阳性的肿瘤细胞。④erbB2/HER2启动子。人原癌基因erbB2/netg/HER2编码一种受体酪氨酸蛋白激酶,属表皮生长因子样受体家族。ErbB2蛋白在乳腺癌、卵巢癌及胃癌等多种恶性肿瘤中表达水平高出正常细胞上百倍,成为一种重要的肿瘤标志。ErbB2与多肽类激素等配体结合,通过激活ras、MAPK等信号分子导致细胞过度增殖和癌变。将治疗基因置于ErbB2调控序列的调控之下,可以使之特异地在上述肿瘤细胞中表达并发挥作用。
number of genes (including ERBB2 , ERBB3 , VEGF , and EPO 5-8 ). However, rational design has not always yielded functional regulators in vivo , mainly because knowledge of both regulatory areas and of endogenous factors affecting transcription factor�DNA
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