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P01193 Recombinant Human ARMET

/MANF 细胞因子/蛋白
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  • ¥988 - 21120
  • Solarbio已认证
  • P01193
  • 北京
  • 2025年07月25日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 库存

      现询

    • 供应商

      北京索莱宝科技有限公司

    • 规格

      1mg/500ug/50ug/10ug

    规格:1mg产品价格:¥21120.0
    规格:500ug产品价格:¥14784.0
    规格:50ug产品价格:¥2600.0
    规格:10ug产品价格:¥988.0
    基本信息
    基因名
    别名Mesencephalic astrocyte-derived neurotrophic factor;Arginine-rich protein;Protein ARMET;ARMET;ARP
    外观(性状)Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
    纯度≥95% as determined by reducing SDS-PAGE.
    储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
    运输条件The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below.
    背景说明Mesencephalic astrocyte-derived neurotrophic factor(MANF) is a secreted protein which belongs to the ARMET family.MANF selectively promotes the survival of dopaminergic neurons of the ventral mid-brain.It modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra.MANF enhances spontaneous,as well as evoked,GABAergic inhibitory postsynaptic currents in dopaminergic neurons.MANF inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.The N-terminal region of ARMET may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response.MANF reduces endoplasmic reticulum (ER) stress and has neurotrophic effects on dopaminergic neurons.Intracortical delivery of recombinant MANF protein protects tissue from ischemic brain injury.MANF has been described as a survival factor for dopaminergic neurons.MANF and a homologous protein,the conserved dopamine neurotrophic factor (CDNF),form a novel evolutionary conserved family of neurotrophic factors.MANF expression was widespread in the nervous system and non-neuronal tissues.
    来源Human Cells
    溶剂Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    内毒素Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.
    单位

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