- ¥1217 - 21245
- Solarbio
- 北京
- P01314
- 2026年08月13日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
相关阅读
香烟烟雾如何加速声带纤维化？CD44-透明质酸轴是关键通路Takara 秋促来袭，提取+反转录+定量套装仅 1200 元abinScience 体内级抗体 全年锁价 低至 ￥1200阿拉丁 22万+ 科研级产品现货速发，品质严控、科研无忧- 详细信息
- 文献和实验
- 技术资料
- 保质期：
Upon receipt, store it immediately at -70°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: <br>2-8°C for 2-7 days; <br>-20°C for 1 months and -70℃ for 3 months.
- 保存条件：
Upon receipt, store it immediately at -70°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: <br>2-8°C for 2-7 days; <br>-20°C for 1 months and -70℃ for 3 months.
- 英文名：
PCSK9
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ¥1217 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ¥3401 |
| 规格： | 500ug | 产品价格： | ¥14909 |
| 规格： | 1mg | 产品价格： | ¥21245 |
| 基因名 | PCSK9 |
| 别名 | Proprotein Convertase Subtilisin/Kexin Type 9; Neural Apoptosis-Regulated Convertase 1; NARC-1; Proprotein Convertase 9; PC9; Subtilisin/Kexin-Like Protease PC9; PCSK9; NARC1 |
| 蛋白号 | Q8NBP7 |
| 种属 | Human |
| 宿主 | HEK293 |
| 产品描述 | Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9 is produced by our Mammalian expression system and the target gene encoding Gln31-Gln692 (Asp374Tyr,Val474Ile, Gly504Arg, Gly670Glu) is expressed with a 6His tag at the C-terminus. |
| 区间范围 | Gln31-Gln692(Asp374Tyr，Val474Ile，Gly504Arg，Gly670Glu) |
| 标签信息 | C-6His |
| 预测分子量 | 13.8&58.2 kDa |
| 表观分子量 | 13.8&58.2 KDa, reducing conditions |
| 纯度 | ≥90% by SDS-PAGE. |
| 内毒素 | <1EU/ug as determined by LAL test. |
| 溶剂 | Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 20% Glycerol, pH 7.4. |
| 复溶 | Reconstituted protein solution can be diluted with distilled water. Always centrifuge tubes before opening. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| 储存条件 | Upon receipt, store it immediately at -70°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: 2-8°C for 2-7 days; -20°C for 1 months and -70℃ for 3 months. |
| 运输条件 | 干冰运输（需要收取干冰费） |
| 背景说明 | Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9/PCSK9 (D374Y) is a gain of function mutant of human PCSK9 protein. Human PCSK9 is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER, the pro domain and mature chain are secreted together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and it plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development. |
| 细胞活性 | No activity experimental data, to be verified. |
| ELISA活性 | Immobilized Recombinant Human LDL R at 5μg/ml (100μl/wel) can bind Recombinant Human PCSK9 . The ED50 of Recombinant Human PCSK9 is 39.17 ng/ml. |
| SPR/BLI活性 | No activity experimental data, to be verified. |
| 研究领域 | 生物制药相关研究 |
| 英文名称 | PCSK9 |
| 中文名称 | PCSK9蛋白 |
| 单位 | 支 |
| 规格 | 10ug ; 50ug ; 500ug ; 1mg |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Construction of Recombinant Human Cytomegalovirus
The use of reverse genetics to generate recombinant viruses allows the researcher to investigate the exact functional significance of particular viral genes during the virus life cycle, by means of their deletion or modification in the viral
AAV-PCSK9 VS传统造模：谁才是动脉粥样硬化研究的最优解？
血浆中低密度脂蛋白胆固醇（LDL-C）水平升高。基于这一原理，研究人员利用AAV将突变型PCSK9（如人D374Y、鼠D377Y）基因递送至肝脏，使实验动物持续分泌高活性PCSK9蛋白。PCSK9过度活跃，加速LDLR降解，阻断胆固醇清除通路，并且配合高脂饲养，血液LDL-C水平迅速升高，从而引起高胆固醇血症、动脉粥样硬化等心血管代谢疾病。 图1 PCSK9与肝细胞表面受体结合 （Manal Alkindi, et al., Can J Cardiol, 2016）
Delivery of Recombinant Adenoviruses to Human Saphenous Vein
The human saphenous vein is the most commonly used conduit for coronary artery bypass grafting owing to its ready availability, ease of harvesting, and favorable surgical handling (1 ). However, it suffers from a progressive decline
技术资料暂无技术资料 索取技术资料
