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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
Store at -20℃,2 years.(Avoid freeze/thaw cycles)
- 保质期:
Store at -20℃,2 years.(Avoid freeze/thaw cycles)
- 英文名:
SH2 Domain Ligand (1)
- 库存:
现询
- 供应商:
北京索莱宝科技有限公司
- 规格:
10mg/5mg/1mg
| 规格: | 10mg | 产品价格: | ¥5110.0 |
|---|---|---|---|
| 规格: | 5mg | 产品价格: | ¥3650.0 |
| 规格: | 1mg | 产品价格: | ¥1460.0 |
| 基本信息 | |
| 产品类型 | 多肽 |
| 单字母序列 | Biotin-ARKRERTYSFGHHA |
| 三字母序列 | Biotin-Ala-Arg-Lys-Arg-Glu-Arg-Thr-Tyr-Ser-Phe-Gly-His-His-Ala |
| 分子式 | C84H128N30O22S1 |
| 分子量 | 1942.2 |
| 纯度 | ≥95% |
| 外观(性状) | 冻干粉;Lyophilized powder |
| 盐体系 | TFA盐;Trifluoroacetate salt |
| 来源 | 合成;Synthetic |
| 储存条件 | Store at -20℃,2 years.(Avoid freeze/thaw cycles) |
| 类别/标签 | 底物和酶抑制剂(Substrate and Enzyme Inhibitors) |
| 规格 | The native peptide ARKRERTYSFGHHA (29944-1) is a synthetic substrate for AKT/PKB/Rprotein kinases. Phophorylation is at the Ser site (Km = 3.9 μM). It also competitively inhibits histone H2B phosphorylation (Ki = 12 μM) by AKT. 天然肽ARKRERTYSFGHHA(29944-1)是AKT/PKB/Rac蛋白激酶的合成底物。磷酸化发生在Ser位点(Km=3.9μM)。它还竞争性地抑制组蛋白H2B磷酸化(Ki=12μM)由AKT。 |
| In Vitro | 未检测 |
| 单位 | 瓶 |
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文献和实验Signaling by Growth Factor Receptors
or an Src homology 2 (SH2) domain. Thus, a multiprotein signaling complex is assembled in the vicinity of the receptor. The ligand determines which receptors are activated, whereas the receptors involved dictate the type of proteins recruited
Autophosphorylation of ligand-activated receptor tyrosine kinases (RTKs) causes recruitment of inactive heterodimeric class IA phosphatidylinositol 3-kinases (PI3Ks) through the interaction of phosphotyrosine residues on the receptor and SRC-homology 2 (SH2) domains
system of the phosphotyrosine peptide binding to the Src SH2 domain.
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