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P01286 Recombinant Human Methi

onine Aminopeptidase 2/METAP2/MAP2 细胞因子/蛋白
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  • ¥1092 - 21120
  • Solarbio已认证
  • P01286
  • 北京
  • 2025年07月25日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 库存

      现询

    • 供应商

      北京索莱宝科技有限公司

    • 规格

      1mg/500ug/50ug/10ug

    规格:1mg产品价格:¥21120.0
    规格:500ug产品价格:¥14784.0
    规格:50ug产品价格:¥3276.0
    规格:10ug产品价格:¥1092.0
    基本信息
    基因名
    别名Methionine aminopeptidase 2;MAP 2;MetAP 2;p67;p67eIF2;Peptidase M;METAP2;MAP2
    外观(性状)Supplied as a 0.2 μm filtered solution of 20mM Tris, 500mM NaCl, 10% glycerol, pH8.0.
    纯度≥95% as determined by reducing SDS-PAGE.
    储存条件Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
    运输条件干冰运输
    背景说明Human Methionine Aminopeptidase 2 (METAP2,MAP2) is a member of the M24 family of metalloproteases.METAPs catalyze the removal of the initiatormethionine residue from nascent peptides and are essential for cell growth.MAP2 binds 2 cobalt or manganese ions and contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues.It is found in all organisms and is especially important because of its critical role in tissue repair and protein degradation.METAP2 plays an important role in the development of different types of cancer and has been a novel target for developing anti-cancerdrugs.This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amno-terminal methionine residue from nascent protein.MAP2 protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR.It also plays a critical role in the regulation of protein synthesis.
    来源Baculovirus
    内毒素Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.
    单位

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