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- 详细信息
- 文献和实验
- 技术资料
- 库存:
现询
- 供应商:
北京索莱宝科技有限公司
- 规格:
1mg/500ug/50ug/10ug
| 规格: | 1mg | 产品价格: | ¥21120.0 |
|---|---|---|---|
| 规格: | 500ug | 产品价格: | ¥14784.0 |
| 规格: | 50ug | 产品价格: | ¥3276.0 |
| 规格: | 10ug | 产品价格: | ¥1092.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Methionine aminopeptidase 2;MAP 2;MetAP 2;p67;p67eIF2;Peptidase M;METAP2;MAP2 |
| 外观(性状) | Supplied as a 0.2 μm filtered solution of 20mM Tris, 500mM NaCl, 10% glycerol, pH8.0. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 运输条件 | 干冰运输 |
| 背景说明 | Human Methionine Aminopeptidase 2 (METAP2,MAP2) is a member of the M24 family of metalloproteases.METAPs catalyze the removal of the initiatormethionine residue from nascent peptides and are essential for cell growth.MAP2 binds 2 cobalt or manganese ions and contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues.It is found in all organisms and is especially important because of its critical role in tissue repair and protein degradation.METAP2 plays an important role in the development of different types of cancer and has been a novel target for developing anti-cancerdrugs.This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amno-terminal methionine residue from nascent protein.MAP2 protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR.It also plays a critical role in the regulation of protein synthesis. |
| 来源 | Baculovirus |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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文献和实验Expression of Recombinant Proteins with Uniform N-Termini
to a self-splicing mini-intein. This fusion construct is expressed in an engineered E. coli strain from which the pepP gene coding for aminopeptidase P has been deleted. We describe a protocol using human cationic trypsinogen as an example to demonstrate
Recombinant Single Globin-Chain Expression and Purification
with methionine aminopeptidase (MAP) cDNA.
of aminopeptidase A expression in cervical carcinoma: role of tumor-stromal interaction and vascular endothelial growth factor. Lab. Invest. 84:639–648. 70. Selvakumar, P., et al. 2004. High expression of methionine aminopeptidase 2 in human colorectal
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