- ￥1092 - 21120
- Solarbio
- P01263
- 北京
- 2025年07月25日
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P00121 Recombinant Human TGF-beta 1/TGFB1 细胞因子/蛋白
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￥312P00102 Recombinant Mouse LIF/Leukemia inhibitory factor 细胞因子/蛋白
￥988P00989 Recombinant Human Baculoviral Iap Repeat-Containing Protein 5/Birc5 细胞因子/蛋白
￥988
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥21120.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥14784.0 |
| 规格： | 50ug | 产品价格： | ￥3276.0 |
| 规格： | 10ug | 产品价格： | ￥1092.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | G1/S-specific cyclin-D2;CCND2; |
| 外观(性状) | Supplied as a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,5mM DTT,pH7.5. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 运输条件 | 干冰运输 |
| 背景说明 | CCND2，also known as G1/S-specific cyclin-D2，is a member of the highly conserved cyclin family.Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event.Cyclins function as regulators of CDK kinases.This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6，whose activity is required for cell cycle G1/S transition.CCND2 is involved in a number of fundamental biological processes such as phosphorylating and inhibiting members of the retinoblastoma (RB) protein family including RB1 and regulating the cell-cycle during G1/S transition.It is also substrate for SMAD3，phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity.Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase.Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.Component of the ternary complex，cyclin D2/CDK4/CDKN1B，required for nuclear translocation and activity of the cyclin D-CDK4 complex. |
| 来源 | E.coli |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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文献和实验3 篇 Nature 连发，解决世纪难题，周期蛋白的毁灭调控蕴含癌症患者的新生
的是两条平行的信号通路，MYC 通路和 cyclin D-CDK-RB 通路。在癌症中 MYC 和 cyclin D-CDK-RB 都是失调的，这与增加的基因组不稳定性相关。虽然已知自噬肿瘤抑制蛋白 AMBRA1 与细胞增殖的控制有关，但其潜在的分子机制尚不清楚。图片来源：Nature Maiani 及其同事通过细胞和分子方法的结合以及体内模型，发现 AMBRA1 通过介导 cyclin D 降解，从而调节其丰度。此外，AMBRA1 是 G1 期到 S 期过度的上游主要调节因子，通过控制从 G1 期
Analysis of RB Action in DNA Damage Checkpoint Response
checkpoint response: (1) transcriptional repression of E2F-regulated genes (cyclin A reporter assay); (2) induction of cell cycle arrest (Brd-U incorporation assay); and (3) inhibition of DNA double-strand break accumulation (phosphorylated-histone H2A.X
Secretion of Recombinant Human Insulin-Like Growth Factor I (IGF-I)
The development of efficient recombinant protein production processes can be a critical factor in whether or not a pharmaceutical therapeutic protein can enter human clinical trials and ultimately the marketplace. This is especially true
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