P00866 Recombinant Mouse Lysos
ome-associated Membrane Glycoprotein 1/LAMP-1/CD107a 细胞因子/蛋白- ￥936 - 17280
- Solarbio
- P00866
- 北京
- 2025年07月25日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥17280.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥12096.0 |
| 规格： | 50ug | 产品价格： | ￥2600.0 |
| 规格： | 10ug | 产品价格： | ￥936.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Lysosome-associated membrane glycoprotein 1;LAMP-1;Lysosome-associated membrane protein 1;120 kDa lysosomal membrane glycoprotein;CD107 antigen-like family member A;LGP-120;Lysosomal membrane glycoprotein A;LGP-A;P2B;CD107a |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Lysosomal associated membrane protein 1 (LAMP1) is an approximately 120 kDa transmembrane glycoprotein that is a major protein component of lysosomal membranes.Mature mouse LAMP1 consists of a 346 amino acid (aa) intralumenal domain (ECD)，a 24 aa transmembrane segment，and a 12 aa cytoplasmic tail.Its lumenal domain is organized into two heavily N-glycosylated regions separated by a Ser/Pro-rich linker that carries a minor amount of O-linked glycosylation.Within the lumenal domain，mouse LAMP1 shares approximately 64% and 82% aa sequence identity with human and rat LAMP1，respectively.The sorting of LAMP1 to lysosomes relies on a tyrosine motif in the cytoplasmic tail.In cytotoxic T cells and mast cells，LAMP1 is expressed in the membranes of intracellular granules that contain effector molecules such as perforin，granzymes，eicosanoids，and histamine.A glycoform of LAMP1 known as M150 is expressed on the surface of activated macrophages where it promotes T cell co-stimulation and a Th1 biased immune response.Exposure of epithelial cells to pathogenic Neisseria bacteria induces the redistribution of LAMP1 to the cell surface where it can be cleaved by the Neisseria IgA1 protease. |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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文献和实验Mouse Strains and Genetic Nomenclature
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Cigarette Smoke Exposure as a Model of Inflammation Associated with COPD
126. Churg, A., Wang, R.D., Tai, H., Wang, X., Xie, C., and Wright, J.L. 2004. Tumor necrosis factor‐{alpha} drives 70% of cigarette smoke‐induced emphysema in the mouse
., and Schwille, P. 2009. Fluorescence correlation spectroscopy in membrane structure elucidation. Biochim. Biophys. Acta 1788:225‐233. Contino, P.B., Hasselbacher, C.A., Ross, J.B.A., and Nemerson, Y. 1994. Use of an oriented transmembrane protein to probe
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