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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥15360.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥10752.0 |
| 规格： | 50ug | 产品价格： | ￥2600.0 |
| 规格： | 10ug | 产品价格： | ￥936.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Fibroblast growth factor receptor 3;FGFR-3;CD333;FGFR3;JTK4;IIIc |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes，including cell growth，differentiation，angiogenesis，wound healing and tumorgenesis.The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding.Four distinct genes encoding closely related FGF receptors，FGF R1-4，are known.All four genes for FGF Rs encode proteins with an N-terminal signal peptide，three immunoglobulin (Ig)-like domains，an acid-box region containing a run of acidic residues between the IgI and IgII domains，a transmembrane domain and the split tyrosine-kinase domain.Multiple forms of FGF R1-3 are generated by alternative splicing of the mRNAs.A frequent splicing event involving FGF R1 and 2 results in receptors containing all three Ig domains，referred to as the α isoform，or only IgII and IgIII，referred to as the β isoform.Only the α isoform has been identified for FGF R3 and FGF R4.Additional splicing events for FGF R1-3，involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons，generate FGF receptors with alternative IgIII domains (IIIb and IIIc).The complex patterns of expression of these receptors as well as the specificity of their interactions with the various FGF ligand family members are under investigation. |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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文献和实验Secretion of Recombinant Human Insulin-Like Growth Factor I (IGF-I)
-like growth factor I (IGF-I) production process in which P. pastoris is used as the recombinant host strain is discussed in this chapter.
Regulator of Epidermal Growth Factor Signaling: Sprouty
Sprouty was first discovered through its downregulatory effect on fibroblast growth factor (FGF) receptor pathway during tracheal development. Sprouty expression is also induced by the epidermal growth factor receptor (EGFR) cascade
Binding In Keratinocyte Growth Factor Receptor. Biochemistry 35, 15640-15645. PCR Assay for FGFR3 -/- Matings Oligos... 5' oligo (JC 14): 5'-GGG CTC CTT ATT GGA CTC GC-3' 3' oligo wild-type allele (JC 41): 5'-AGG TAT AGT TGC CAC GAT CGG
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