- ￥910 - 27000
- Solarbio
- P00808
- 北京
- 2025年07月25日
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- 详细信息
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥27000.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥18000.0 |
| 规格： | 50ug | 产品价格： | ￥2730.0 |
| 规格： | 10ug | 产品价格： | ￥910.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Leukocyte immunoglobulin-like receptor subfamily B member 4;Mast cell surface glycoprotein Gp49B;CD85k;Lilrb4;Gp49b |
| 中文名称 | Recombinant Mouse LILRB4/CD85k/ILT3 |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCl, 100mM Glycine, pH 7.5. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Mouse Leukocyte Immunoglobulin-like Receptor Subfamily B Member 4 (LILRB4/CD85k/ILT3) is an approximately transmembrane glycoprotein that negatively regulates immune cell activation.Mouse LILRB4 consists of a 215 amino acid (aa) extracellular domain with two Ig-like domains，a 22 aa transmembrane segment，and a 75 aa cytoplasmic domain with 3 immunoreceptor tyrosine-based inhibitory motifs (ITIM).Within the ECD，mouse LILRB4 shares 45% and 77% aa sequence identity with human and rat LILRB4，respectively.Alternative splicing of mouse LILRB4 generates a potentially soluble isoform that lacks the transmembrane segment.LILRB4 is expressed on dendritic cells (DC)，monocytes，macrophages，and vascular endothelial cells (EC).Ligation of LILRB4 triggers ITIM-mediated inhibition of cellactivating signaling，leading to enhanced immune tolerance and reduced allogeneic graft rejection.Soluble LILRB4 induces the differentiation of CD8+ T suppressor cells (Ts) that can inhibit the effector functions of CD4+ Th cells and CD8+ CTL.In turn，CD8+ Ts cells induce LILRB4 up-regulation and a tolerogenic phenotype in monocytes，DC，and EC. |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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P00808 Recombinant Mouse LILRB4/CD85k/ILT3 细胞因子/蛋白
￥910 - 27000
