- ￥832 - 21120
- Solarbio
- P00789
- 北京
- 2025年07月25日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥21120.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥14784.0 |
| 规格： | 50ug | 产品价格： | ￥2288.0 |
| 规格： | 10ug | 产品价格： | ￥832.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Poliovirus Receptor-Related Protein 1;Herpes Virus Entry Mediator C;Herpesvirus Entry Mediator C;HveC;Herpesvirus Ig-Like Receptor;HIgR;Nectin-1;CD111;PVRL1;HVEC;PRR1 |
| 中文名称 | Recombinant Human Nectin-1/PVRL1 |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Nectin-1 is a type I transmembrane glycoprotein belonging to the Ig superfamily.Nectin-1 promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers.Heterophilic interactions have been detected between Nectin-1 and Nectin-3 and between Nectin-1 and Nectin-4.Nectin ECDs contain three Ig like domains: an N terminal V type that mediates ligand binding，and two C2 type.Nectin-1 binds viral Glycoprotein D to mediate Herpesvirus (but not Poxvirus) entry into vaginal mucosa，sensory neurons and fibroblasts.In forming adherens junctions and synapses，Nectin-1 and Nectin-3 initiate cell-cell interactions，recruiting αvβ3 integrin extracellularly and cadherins intracellularly through afadin and other junctional proteins.These interactions organize the cytoskeleton，strengthen attachment to basement membrane and promote further cell-cell connections.Nectin-1 and Nectin-3 have been found to localize assymetrically along the chemical synapse，with Nectin-1 primarily on the axonal side and Nectin-3 on the dendritic side.Deficiency of Nectin-1 can result in cleft lip/palate ectodermal dysplasia.Nectin-1 downregulation in epithelial cancers is mediated in part by ectodomain shedding，but it may contribute to invasiveness. |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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