- ￥832 - 21120
- Solarbio
- P00778
- 北京
- 2025年07月25日
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￥988
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥21120.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥14784.0 |
| 规格： | 50ug | 产品价格： | ￥2288.0 |
| 规格： | 10ug | 产品价格： | ￥832.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b;IgG Fc Receptor II-b;CDw32;Fc-Gamma RII-b;Fc-Gamma-RIIb;FcRII-b;CD32;FCGR2B;FCG2;IGFR2 |
| 中文名称 | Recombinant Human Fc gamma RIIB/CD32b |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG.The human CD32 group consists of FcγRIIA，FcγRIIB，and FcγRIIC proteins that share 94-99% sequence identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains.FcγRII protein is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin.FcγRIIB has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) and delivers an inhibitory signal upon ligand binding.Ligation of FcγRIIB on B cells down-regulates antibody production and in some circumstances may promote apoptosis.Co-ligation of FcγRIIB on dendritic cells inhibits maturation and blocks cell activation.FcγRIIB may also be a target for monoclonal antibody therapy for malignancies.FcγRIIB plays an important negative-regulating role through modulating the signals from activation receptors. |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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文献和实验Assessing Fc Glycan Heterogeneity of Therapeutic Recombinant Monoclonal Antibodies Using NP-HPLC
Recombinant monoclonal antibodies (rMAbs) are becoming major human therapeutics to treat life-threatening diseases such as cancer. These rMAbs are produced using either in vitro cell culture processes or transgenic technology in animals
Capture and Qualitative Analysis of the Activated Fc Receptor Complex from Live Cells
Bajno, L., Peng, X.R., Schreiber, A.D., Moore, H.P., Trimble, W.S., and Grinstein, S. 2000. Focal exocytosis of VAMP3‐containing vesicles at sites of phagosome formation. J. Cell Biol. 149:697‐706.
Introduction of human 14-3-3 proteins
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