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- 文献和实验
- 技术资料
- 保质期：
Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: <br>2-8°C for 2-7 days under sterile conditions after redissolves; <br>-20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; <br>-20°C to -70℃ for 12 months in lyophilized state.
- 保存条件：
Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: <br>2-8°C for 2-7 days under sterile conditions after redissolves; <br>-20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; <br>-20°C to -70℃ for 12 months in lyophilized state.
- 英文名：
Mesothelin
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ¥780.00 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ¥1560.00 |
| 规格： | 500ug | 产品价格： | ¥7200.00 |
| 规格： | 1mg | 产品价格： | ¥12000.00 |
| 基因名 | Mesothelin |
| 别名 | Megakaryocyte potentiating factor; mesothelin; Pre-pro-megakaryocyte-potentiating factor; soluble MPF mesothelin related protein; CAK1; MPF; MSLN; SMR; CAK1; CAK1 antigen |
| 蛋白号 | AAH09272.1 |
| 种属 | Human |
| 宿主 | HEK293 |
| 产品描述 | Recombinant Human Mesothelin is produced by our Mammalian expression system and the target gene encoding Glu296-Ser598 is expressed with a 6His tag at the C-terminus. |
| 区间范围 | Glu296-Ser598 |
| 标签信息 | C-6His |
| 预测分子量 | 35-50 kDa |
| 表观分子量 | 35-50 KDa, reducing conditions |
| 纯度 | ≥95% by SDS‐PAGE. |
| 内毒素 | <1EU/ug as determined by LAL test. |
| 溶剂 | Lyophilized from a 0.2 μm filtered solution of 20 mM Hepes-NaOH, 50 mM NaCl, 8% Trehalose, 0.05% Tween 80, pH 8.0. |
| 复溶 | Reconstituted protein solution can be diluted with distilled water. Always centrifuge tubes before opening. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| 储存条件 | Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: 2-8°C for 2-7 days under sterile conditions after redissolves; -20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; -20°C to -70℃ for 12 months in lyophilized state. |
| 运输条件 | 冷冻运输 |
| 背景说明 | Mesothelin is a cell surface glycoprotein whose expression is limited to mesothelial cells of the serosa (pleura, pericardium, and peritoneum) and epithelial cells of the trachea, tonsils, fallopian tube, and kidneys. Mesothelin plays an important role in cell survival, proliferation, migration, invasion, tumor progression, and resistance to chemotherapy. The overexpression of mesothelin can activate NF-κB and signal transducer and activator of transcription 3 (Stat3), inhibit apoptotic signaling and TNF-α-induced apoptosis, and accelerate the G1–S transition. Mesothelin is also found overexpressed in various cancers, including malignant mesothelioma, pancreatic or ovarian carcinoma, sarcomas and in some gastrointestinal or pulmonary carcinomas. As a result of its limited expression in normal tissues, mesothelin has been reported as an ideal tumor-associated marker for the development of targeted therapy. |
| 细胞活性 | No activity experimental data, to be verified. |
| ELISA活性 | Immobilized Recombinant Human Mesothelin at 2 μg/ml (100μl/wel) can bind Anti-Human Mesothelin mAb . The ED50 of Anti-Human Mesothelin mAb is 4.88 ng/ml. |
| SPR/BLI活性 | Loaded Anti-Human Mesothelin mAb-Fc on Protein A Biosensor, can bind Human Mesothelin-His with an affinity constant of 0.1 nM as determined in BLI assay. |
| 研究领域 | 生物制药相关研究 |
| 英文名称 | Mesothelin |
| 中文名称 | Mesothelin蛋白 |
| 单位 | 支 |
| 规格 | 10ug ; 50ug ; 500ug ; 1mg |
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