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- 详细信息
- 文献和实验
- 技术资料
- 库存:
现询
- 供应商:
北京索莱宝科技有限公司
- 规格:
1mg/500ug/50ug/10ug
| 规格: | 1mg | 产品价格: | ¥8160.0 |
|---|---|---|---|
| 规格: | 500ug | 产品价格: | ¥6240.0 |
| 规格: | 50ug | 产品价格: | ¥1560.0 |
| 规格: | 10ug | 产品价格: | ¥520.0 |
【本资料源自公开渠道,如需(此处)屏蔽,请联系删除】
标题:Differences in epithelial-mesenchymal-transition in paraquat-induced pulmonary fibrosis in BALB/C and BALB/C (nu/nu) nude mice
成员:Yegang Hu, Chuanyun Qian, Huiling Sun, Qiankui Li, Jinde Wang, Hairong Hua, Zichao Dai, Jintao Li, Tao Li, Yi Ding, Xinwang Yang, Wei Zhang
论文因子:6.53 发表期刊:BIOMEDICINE & PHARMACOTHERAPY pmid:34507117
| 基本信息 | |
| 基因名 | |
| 别名 | Interleukin-21 receptor;IL-21 receptor;IL-21R;Il21r;Nilr |
| 中文名称 | Recombinant Mouse Interleukin-21 Receptor/IL-21R |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family,type 4 subfamily.IL-21R is expressed mainly on B cells,NK cells,and activated T cells,but is also found on dendritic cells,alternatively activated macrophages,intestinal lamina propria fibroblasts and epithelial cells,and keratinocytes.Both IL-21 and IL-4 are necessary for efficient B cell IgG1 production and normal germinal center architecture.B cell IL-21 R engagement induces Blimp-1(which mediates plasma cell differentiation),and is important for memory responses.IL-21R engagement on mouse NK cells enhances their cytotoxic activity and IFN-γ production.IL-21R engagement on CD8+ T cells aids control of viral infection and tumor growth IL-21R is also necessary for sufficient numbers of regulatory T cells to combat chronic inflammation.IL-21R expression is often up-regulated in allergic skin inflammation,systemic lupus erythematosus and diffuse large B cell lymphoma (DLBCL). |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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文献和实验【本资料源自公开渠道,如需(此处)屏蔽,请联系删除】
标题:Differences in epithelial-mesenchymal-transition in paraquat-induced pulmonary fibrosis in BALB/C and BALB/C (nu/nu) nude mice
成员:Yegang Hu, Chuanyun Qian, Huiling Sun, Qiankui Li, Jinde Wang, Hairong Hua, Zichao Dai, Jintao Li, Tao Li, Yi Ding, Xinwang Yang, Wei Zhang
论文因子:6.53 发表期刊:BIOMEDICINE & PHARMACOTHERAPY pmid:34507117
Immunity:厦门大学韩家淮团队揭示 PELO 控制 NOD 样受体家族蛋白寡聚化组装和激活的机制
的炎症小体(Inflammasome),NOD2 等形成的 Nodosome,从而激活 NF-κB 通路、MAPK 通路、细胞焦亡等,释放 TNFα,IL-1β 和 IL-18 等炎性细胞因子,介导下游一系列免疫炎症级联反应【1,2】。这是机体最为基本的天然免疫防御反应之一,在机体清除病原感染和内源危险信号中发挥至关重要的作用。在人体中,多个 NLR 基因突变导致的异常激活也被发现参与了脓毒症、炎性肠病等多种重大炎性疾病的病理进程。 NLR 家族蛋白在结构上都含有一个核苷酸结合寡聚化结构域
我们知道,PeproTech的所有细胞因子和蛋白均为冻干粉,这使得运输非常便捷,只要常温即可。而且,细胞因子和蛋白冻干粉非常稳定,在-20℃或-80℃条件下可保存数年。冻干粉在使用前需进行溶解,然后以液体形式加到培养体系或注射入动物体内。溶解步骤非常关键,因溶解不好会导致细胞因子或蛋白的失活,这也是很多用户在实际使用中经常遇到的问题。 那么,应该如何进行正确的溶解呢? 下面我们以Recombinant Human IL-4 (重组人IL-4,产品编号:200-04)的说明书为例
大家知道,PeproTech的所有细胞因子和蛋白均为冻干粉,这使得运输非常便捷,只要常温即可。而且,细胞因子和蛋白冻干粉非常稳定,在-20o C或-80o C条件下可保存数年。冻干粉在使用前需进行溶解,然后以液体形式加到培养体系或注射入动物体内。溶解步骤非常关键,因溶解不好会导致细胞因子或蛋白的失活,这也是很多用户在实际使用中经常遇到的问题。 应该如何进行正确的溶解呢? 下面我们以Recombinant Human IL-4 (重组人IL-4,产品编号:200-04
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