- ￥520 - 10080
- Solarbio
- P00468
- 北京
- 2025年07月25日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥10080.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥7056.0 |
| 规格： | 50ug | 产品价格： | ￥1248.0 |
| 规格： | 10ug | 产品价格： | ￥520.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Cytotoxic T-lymphocyte protein 4;Cytotoxic T-lymphocyte-associated antigen 4;CTLA-4;CD152;Ctla4 |
| 中文名称 | Recombinant Mouse CTLA-4/CD152/Cytotoxic T-lymphocyte Protein 4 |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Mouse Cytotoxic Tlymphocyte 4(CTLA-4，CD152)，is a type I transmembrane T cell inhibitory molecule.mouse CTLA4 cDNA encodes 223 amino acids (aa) including a 35 aa signal sequence，a 126 aa extracellular domain (ECD) with one Ig-like V-type domain，a 21 aa transmembrane (TM) sequence，and a 41 aa cytoplasmic sequence.Within the ECD，Mouse CTLA-4 shares 68% aa sequence identity with human.CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells.CTLA4 transmits an inhibitory signal to T cells，whereas CD28 transmits a stimulatory signal.Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their functions.T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4.Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus(SLE)，Gravesdisease(GRD)，Celiac disease type3(CELIAC3) and Hepatitis B virus infection(HBVinfection). |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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文献和实验Preparation of Recombinant Protein Spotted Arrays for Proteome‐Wide Identification of Kinase Targets
., Lau, L., Robinson, J.T., Price, J., Sherlock, S.P., Wang, H., Zhang, B., Chen, Z., Tangsombatvisit, S., Jarrell, J.A., Utz, P.J., and Dai, H. 2011. Plasmonic substrates for multiplexed protein microarrays with femtomolar sensitivity and broad dynamic
randomly paired light (L) and heavy (H) chain coding regions under transcriptional control of P lac . The H chain coding region is fused in-frame with the phage gene, Δ gIII , coding for a truncated version of the phage surface protein pIII (ΔpIII
(5 ). Recently, it has been found that TNF-α has profound effects on dendritic cell (DC) maturation (6 ) and activation (7 ). In addition, it has also been reported to stimulate T-cell proliferation (8 ) and to activate cytotoxic T-cells
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