P00202 Recombinant Mouse TIGIT

Recombinant Mouse T cell Immunoreceptor with Ig and ITIM domains is produced by our Mammalian expression system and the target gene encoding Gly26-Phe135 is expressed with a 6His tag at the C-terminus.

基本信息
基因名
别名	T-cell immunoreceptor with Ig and ITIM domains;TIGIT;V-set and transmembrane domain-containing protein 3;VSTM3
外观(性状)	Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度	≥95% as determined by reducing SDS-PAGE.
储存条件	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输条件	The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below.
背景说明	T cell immunoreceptor with Ig and ITIM domains (TIGIT)，also called WUCAM，VSIG9 and Vstm3，is a member of the CD28 family within the Ig superfamily of proteins.TIGIT contains an immunoglobulin variable domain，a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM)，and is expressed on regulatory，memory，activated T cells and NK cells.TIGIT binds to CD155(PVR) that appear on dendritic cells (DC)，macrophages and endothelium with high affinity，and CD112(PVRL2) with lower affinity，but not CD113 (PVRL3).TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10，but inhibit the macrophage activation.Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges，while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.
来源	Human Cells
溶剂	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素	Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.
单位	支