- ￥520 - 10080
- Solarbio
- P00423
- 北京
- 2025年07月25日
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- 详细信息
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥10080.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥3640.0 |
| 规格： | 50ug | 产品价格： | ￥1040.0 |
| 规格： | 10ug | 产品价格： | ￥520.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Ubiquitin-Conjugating Enzyme E2 Variant 1;UEV-1;CROC-1;TRAF6-Regulated IKK Activator 1 Beta Uev1A;UBE2V1;CROC1;UBE2V;UEV1;P/OKcl.19 |
| 中文名称 | Recombinant Human UBE2V1/Uev1a (Mms2) |
| 外观(性状) | Supplied as a 0.2 μm filtered solution of 50mM HEPES, 100mM NaCl, pH 8.0. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 运输条件 | 干冰运输 |
| 背景说明 | Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) is a member of the Ubiquitin-conjugating (E2) enzyme family.The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue，rendering it catalytically inactive on its own.However，in the cytoplasm UBE2V1 is able to form a catalytically active complex with UBE2N/Ubc13，which mediates the synthesis Lys63-linked Ubiquitin chains and is required for NF-kappa B activation.UBE2V1 is required for UBE2N (Ubc13)/UBE2V1 Complex-dependent Lys63-linked Ubiquitin chain formation.More specifically，UBE2V1 orients the Ubiquitin molecule to favor linkage at Lys63 via a non-covalent interaction with the Ubiquitin molecule.The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys63.This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome.UBE2V1 plays a role in the activation of NF-kappa-B mediated by IL1B，TNF，TRAF6，and TRAF2.It mediates transcriptional activation of target genes.UBE2V1 also controls the progress through the cell cycle and differentiation，the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. |
| 来源 | E.coli |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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P00423 Recombinant Human UBE2V1/Uev1a (Mms2) 细胞因子/蛋白
￥520 - 10080
