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P00386 Recombinant Human IgG1

Fc/Ig gamma-1 chain C region/IGHG1 细胞因子/蛋白
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  • ¥312 - 6240
  • Solarbio已认证
  • P00386
  • 北京
  • 2025年07月25日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 库存

      现询

    • 供应商

      北京索莱宝科技有限公司

    • 规格

      1mg/500ug/50ug/10ug

    规格:1mg产品价格:¥6240.0
    规格:500ug产品价格:¥4732.0
    规格:50ug产品价格:¥936.0
    规格:10ug产品价格:¥312.0
    基本信息
    基因名
    别名g gamma-1 chain C region;IGHG1
    中文名称Recombinant Human IgG1 Fc/Ig gamma-1 chain C region/IGHG1
    外观(性状)Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
    纯度≥95% as determined by reducing SDS-PAGE.
    储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
    运输条件The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below.
    背景说明As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass through the human placenta,Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells,and constitutes 75% of serum immunoglobulins in humans.IgG antibodies protect the body against the pathogens by agglutination and immobilization,complement activation,toxin neutralization,as well as the antibody-dependent cell-mediated cytotoxicity (ADCC).IgG tetramer contains two heavy chains (50 kDa ) and two light chains (25 kDa) linked by disulfide bonds,that is the two identical halves form the Y-like shape.IgG is digested by pepsin proteolysis into Fab fragment (antigen-binding fragment) and Fc fragment (crystallizable fragment).IgG1 is most abundant in serum among the four IgG subclasses (IgG1,2,3 and 4) and binds to Fc receptors (FcγR ) on phagocytic cells with high affinity.
    来源Human Cells
    溶剂Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    内毒素Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.
    单位

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    图标文献和实验
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    • 蛋白防御功能之免疫球蛋白

      ;1、γ2γ3和λ4重链上均存在有同种异型标记,目前已发现:Glma、x、f、z;G2mn;G3mgl、g5、b0、b1、b3、b4、b5、c3、c5、s、t、u、v;G4m4a、4b。共20种左右。其中G表示λ链,1、2、3或4表示亚类λ1、λ2、λ3和λ4,m代表标记(marker)。 除Glmf和z位于IgG1分子的Cγ1区外,其余的Gm均位于Fc部位。一条γ链

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    ¥312 - 6240