P00166 Recombinant Human MIF/

Recombinant Human Macrophage migration inhibitory factor is produced by our E.coli expression system and the target gene encoding Met1-Ala115 is expressed.

基本信息
基因名
别名	Macrophage migration inhibitory factor;MIF;MMIF;Glycosylation-inhibiting factor;GLIF;L-dopachrome tautomerase;Phenylpyruvate tautomerase
外观(性状)	Supplied as a 0.2 μm filtered solution of 20mM PB,150mM NaCl,20% Glycerol,pH7.4.
纯度	≥95% as determined by reducing SDS-PAGE.
储存条件	Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
运输条件	干冰运输
背景说明	Human MIF is a 12.5 kDa，115 amino acid (aa) nonglycosylated polypeptide that is synthesized without asignal sequence.Secretion occurs nonclassically via an ABCA1 transporter.Pro-inflammatory cytokine.Involved in the innate immune response to bacterial pathogens.The expression of MIF at sites ofinflammation suggests a role as mediator in regulating the function of acrophages in host defense.Counteracts the anti-inflammatory activity of glucocorticoids.Has phenylpyruvate tautomerase anddopachrome tautomerase activity (in vitro)，but the physiological substrate is not known.It is not clearwhether the tautomerase activity has any physiological relevance，and whether it is important for cytokineactivity.
来源	E.coli
内毒素	Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.
单位	支