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- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
BCH001
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- CAS号：
384859-58-9
- 规格：
5mg/1mg/10mg/25mg/50mg
| 规格： | 5mg | 产品价格： | ¥540.00 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ¥210.00 |
| 规格： | 10mg | 产品价格： | ¥890.00 |
| 规格： | 25mg | 产品价格： | ¥1890.00 |
| 规格： | 50mg | 产品价格： | ¥3490.00 |
| CAS | 384859-58-9 |
| 英文名称 | BCH001 |
| 分子式 | C20H15F3N2O5 |
| 分子量 | 420.34 |
| 规格 | 5mg ; 1mg ; 10mg ; 25mg ; 50mg |
| 溶解性 | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| 纯度 | ≥98% |
| 外观(性状) | White to yellow Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| 运输条件 | 冷藏运输 |
| MDL | MFCD02932975 |
| SMILES | CCOC(=O)C1=CN=C2C=CC(=CC2=C1NC3=CC=CC=C3C(=O)O)OC(F)(F)F |
| InChIKey | FWJMVZAVAUGMDX-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H15F3N2O5/c1-2-29-19(28)14-10-24-15-8-7-11(30-20(21，22)23)9-13(15)17(14)25-16-6-4-3-5-12(16)18(26)27/h3-10H，2H2，1H3，(H，24，25)(H，26，27) |
| PubChem CID | 1043578 |
| 靶点 | PAPD5 |
| 通路 | Cell Cycle;DNA Damage/DNA Repair |
| 背景说明 | BCH001 是选择性的 PAPD5 抑制剂。 |
| 生物活性 | BCH001， a quinoline derivative， is a specific PAPD5 inhibitor. BCH001 restores telomerase activity and telomere length in dyskeratosis congenita (DC) induced pluripotent stem cells. BCH001 shows no inhibition of poly(A)-specific ribonuclease (PARN) or several other canonical and non-canonical polynucleotide polymerases. BCH001 is used to regulate aging[1]. |
| In Vitro | BCH001 (100 nM-1 μM; for 7 days) reduces telomerase RNA component (TERC) RNA oligo-adenylation and increases steady state TERC RNA levels in PARN-mutant iPSC clones. BCH001 causes few transcriptome-wide changes and rescues other ncRNAs disrupted by PARN mutations[1].BCH001 (1 μM， 24-72 h) has no adverse impact on cell growth， cell cycle， or apoptosis in induced pluripotent stem cells (iPSCs) from DC[1].BCH001 inhibits ATP- and dose-dependently recombinant PAPD5 (rPAPD5) in vitro. PAPD5 is a non-canonical polymerase that oligoadenylates and destabilizes telomerase RNA component (TERC)[1]. |
| 数据来源文献 | [1]. Neha Nagpal， et al. Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells. Cell Stem Cell. 2020 Jun 4;26(6):896-909.e8. |
| 单位 | 瓶 |
| 表格1 | |*|1mg|5mg|10mg|$$|1mM|2.379mL|11.8951mL|23.7903mL|$$|5mM|0.4758mL|2.379mL|4.7581mL|$$|10mM|0.2379mL|1.1895mL|2.379mL| |
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