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- 详细信息
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Famotidine
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
76824-35-6
- 规格：
1g
| 基本信息 | |
| CAS | No.76824-35-6 |
| 中文名称 | 法莫替丁 |
| 英文名称 | Famotidine |
| 别名 | MK208 |
| 分子式 | C8H15N7O2S3 |
| 分子量 | 337.45 |
| 溶解性 | Soluble in DMSO ≥10mg/mL;Soluble in Water ＜ 1mg/mL |
| 纯度 | ≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 616-396-9 |
| MDL | MFCD00079297 |
| SMILES | N=C(NS(=O)(N)=O)CCSCC1=CSC(NC(N)=N)=N1 |
| 靶点 | Histamine Receptor |
| 通路 | GPCR & G Protein;Neuronal Signaling;Immunology & Inflammation |
| 背景说明 | 是组胺H2受体拮抗剂。 |
| 生物活性 | Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion. |
| IC50 | Histamine H2 Receptor[1]. |
| In Vitro | Famotidine (MK-208) is a histamine H2-receptor antagonist that inhibits stomach acid production， and it is commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD). Famotidine (MK-208) Group(2 mg/kg/day) were significantly lower than the equivalent parameters for the Control Group on both the third and seventh days post-surgery. Famotidine (MK-208) exerts detrimental effects on the anastomotic bursting pressure and hydroxyproline content of perianastomotic tissues in the colon of rats[1]. Famotidine (MK-208) increased the transgastric potential difference (PD) and promoted the recovery of decreased transgastric PD induced by acidified ethanol in rats. The preventive effect of famotidine on gastric lesions is attributable not only to suppression of acid secretion but to activation of the gastric mucosal defensive mechanisms[2]. |
| 数据来源文献 | [1]. Inan， A.， et al.， Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats. Clinics (Sao Paulo)， 2009. 64(6): p. 567-70. [2]. Miyata， K.， et al.， Studies on the mechanism for the gastric mucosal protection by famotidine in rats. Jpn J Pharmacol， 1991. 55(2): p. 211-22. |
| 单位 | 瓶 |
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IF1290 法莫替丁 抑制剂/拮抗剂/激动剂 索莱宝
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