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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
3,6-Dihydroxyflavone
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
108238-41-1
- 规格：
100mg/50mg/25mg/10mg/5mg
| 规格： | 100mg | 产品价格： | ￥2590.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥1840.0 |
| 规格： | 25mg | 产品价格： | ￥1290.0 |
| 规格： | 10mg | 产品价格： | ￥790.0 |
| 规格： | 5mg | 产品价格： | ￥490.0 |
| 基本信息 | |
| CAS | No.108238-41-1 |
| 中文名称 | 3,6-二羟基黄酮 |
| 英文名称 | 3,6-Dihydroxyflavone |
| 别名 | ;6-Hydroxyflavonol;3，6-dihydroxy-flavone;Uracil，5-chloro |
| 分子式 | C15H10O4 |
| 分子量 | 254.24 |
| 溶解性 | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| 纯度 | ≥98% |
| 外观(性状) | Light yellow to light brown Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00143082 |
| SMILES | C1=CC=C(C=C1)C2=C(C(=O)C3=C(O2)C=CC(=C3)O)O |
| InChIKey | XHLOLFKZCUCROE-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H10O4/c16-10-6-7-12-11(8-10)13(17)14(18)15(19-12)9-4-2-1-3-5-9/h1-8，16，18H |
| PubChem CID | 688659 |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | 是一种化合物，具有抗癌活性。 |
| 生物活性 | 3，6-Dihydroxyflavone is an anti-cancer agent. 3，6-Dihydroxyflavone dose- and time-dependently decreases cell viability and induces apoptosis by activating caspase cascade， cleaving poly (ADP-ribose) polymerase (PARP). 3，6-Dihydroxyflavone increases intracellular oxidative stress and lipid peroxidation[1]. |
| In Vitro | 3，6-dihydroxyflavone dose- and time-dependently decreases cell viability and induces Apoptosis by activating Caspase cascade， cleaving poly (ADP-ribose) polymerase (PARP). The anti-cancer effects of 3，6-dihydroxyflavone are associated with the generation of Reactive Oxygen Species， the altered glutathione-redox balance as significantly decreased glutathione (GSH) and its ratio to gluthatione disulfide (GSSG)， and the accumulation of lipid peroxidation indicator malondialdehyde. Addition of antioxidant N-acetylcysteine (NAC) prevents the elevation of Reactive Oxygen Species induced by 3，6-dihydroxyflavone and partially suppresses the cytotoxic effects. Furthermore， 3，6-dihydroxyflavone reduces cell membrane fluidity and induces the loss of mitochondrial membrane potential. 3，6-Dihydroxyflavone was also found to modulate the activities of mitogen-activated protein kinase (MAPK) family members， which includes increased protein kinase of 38 kDa (p38)， c-Jun N-terminal kinase (JNK)， and decreased extracellular signal-regulated kinase (ERK) activation. The effect of 3，6-dihydroxyflavone on MAPKs pathway could be abrogated by co-treatment with NAC.3，6-dihydroxyflavone increases intracellular oxidative stress and lipid peroxidation， thereby affecting the physical and functional properties of plasma membrane， as well as MAPKs signal pathway， which are likely to play a role in the 3，6-dihydroxyflavone-induced HL-60 cell cytotoxicities.[1] |
| 数据来源文献 | [1]. Chang H， et al. 3，6-Dihydroxyflavone induces apoptosis in leukemia HL-60 cell via reactive oxygen species-mediated p38 MAPK/JNK pathway. Eur J Pharmacol. 2010;648(1-3):31-38. |
| 单位 | 瓶 |
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文献和实验, we may find much more references regarding this issue. http://books.google.com/books?id=3mgPzNFjcWAC&pg=PA51&lpg=PA51&dq=gsk+tyrosine+phosphorylation+and+activity&source=bl&ots=x5ueTldpez&sig=CqRFJleXtEBn9OfelhODPAc28xs&hl=en&ei=KerNSu-XGcem8Abm-qmABA&sa=X&oi=book_result&ct
)及磷脂过氧化氢谷胱甘肽氧化酶(PHGSH�x)的组成成分。GSH�x中每克分子酶四聚体含有4克原子硒，硒半胱氨酸的硒醇是酶的催化中心。该酶在人体内起抗氧化作用，能催化GSH与胞液中的过氧化物反应，防止过氧化物对机体的损伤。GSH�x活力下降，线粒体不可逆地失去容积控制和收缩能力并最后破裂。缺硒所致肝坏死可能是过氧化物代谢受损的结果。PHGSH�x与GSH�x不同，它存在于肝和心肌细胞线粒体内膜间隙中，作用是抗氧化、维持线粒体的完整，避免脂质过氧化物伤害。此外，I型碘甲腺原氨酸5′－脱碘酶(5′�ID
of complex and protein alone with the naked eye or a light microscope, crystals of covalently Cy5?labeled DNA can be directly used for X?ray diffraction data collection. Curr. Protoc. Nucleic Acid Chem. 46:7.15.1?7.15.8. © 2011 by John Wiley & Sons
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