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- 2025年12月17日
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- 详细信息
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
ICRF-187 Hydrochloride
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
149003-01-0
- 规格：
25mg/5mg/100mg/50mg/10mg
| 规格： | 25mg | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥302.0 |
| 规格： | 100mg | 产品价格： | ￥1340.0 |
| 规格： | 50mg | 产品价格： | ￥970.0 |
| 规格： | 10mg | 产品价格： | ￥490.0 |
是一种胞内铁螯合剂，能够减少氧自由基 的生成，是topoisomerase II的抑制剂。
| 基本信息 | |
| CAS | No.149003-01-0 |
| 中文名称 | 右雷佐生盐酸盐 |
| 英文名称 | ICRF-187 Hydrochloride |
| 别名 | 右雷佐生盐酸盐;右丙亚胺盐酸盐;Dexrazoxanehydrochloride;DexrazoxaneHCl;碘柳醚;磺醚柳胺 |
| 分子式 | C11H16N4O4·HCl |
| 分子量 | 304.73 |
| 溶解性 | Soluble in Water/DMSO |
| 纯度 | ≥99% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00912156 |
| SMILES | C[C@H](N(C1)CC(NC1=O)=O)CN(C2)CC(NC2=O)=O.[xHCl] |
| 靶点 | TopoII |
| 通路 | DNA Damage/DNA Repair |
| 背景说明 | 是一种胞内铁螯合剂,能够减少氧自由基 的生成,是topoisomerase II的抑制剂。 |
| 生物活性 | Dexrazoxane is a potent metal ion chelator as well as being a catalytic inhibitor of DNA topoisomerase II. [2]Dexrazoxane (ICRF-187) is the only clinically approved cardioprotective agent against anthracycline cardiotoxicity. Its activity has traditionally been attributed to the iron-chelating effects of its metabolite with subsequent protection from oxidative stress. [1] |
| In Vitro | Dexrazoxane may protect cardiomyocytes via its catalytic TOP2 inhibitory activity rather than iron-chelation activity.[1] |
| 细胞实验 | Triple-treatment with systemic dexrazoxane was superior to single dosage and completely prevented lesions after s.c. daunorubicin and doxorubicin. Low-dose i.l. dexrazoxane was effective in protecting as well.Dexrazoxane is extremely effective and apparently quite specific in protecting against lesions after s.c. doxorubicin and daunorubicin.[2] |
| 动物实验 | Mice were injected s.c. with daunorubicin or doxorubicin. Systemic N-acetylcysteine，alfa-tocoferol，amifostine，merbarone，aclarubicin，ADR-925，and EDTA were administered i.p. immediately hereafter or as a triple-treatment over six hours. Intralesional(i.l.)adjuvants were injected immediately after and into the same area as the anthracycline. The frequency，duration，and sizes of wounds were observed until complete healing of all wounds.[2] |
| 数据来源文献 | [1]. Vavrova A， Jansova H， Mackova E， Machacek M， Haskova P， Tichotova L， Sterba M， Simunek T. Catalytic inhibitors of topoisomerase II differently modulate the toxicity of anthracyclines in cardiac and cancer cells. PLoS One. 2013 Oct 7;8(10):e76676. [2]. Langer SW， Sehested M， Jensen PB. Dexrazoxane is a potent and specific inhibitor of anthracycline induced subcutaneous lesions in mice. Ann Oncol. 2001 Mar;12(3):405-10. [3]. |
| 单位 | 瓶 |
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II0720 右雷佐生盐酸盐 抑制剂/拮抗剂/激动剂 索莱宝
￥302 - 1340
