IN0430 氯化两面针碱 抑制剂/拮抗剂/激动剂 索莱宝

使用本产品的案例（仅供参考）

In Vivo

Mice (Four-to-fve-week-old BALB/c male mice; 8 or 16 mg/kg/week Nitidine chloride/NC，腹部注射，twice a day）

H1688 cells or A549 cells (approximately 1× 10⁷) were injected subcutaneously into the right fank of BALB/c mice.   Considering that NC is poorly absorbed, we treated the mice with NC by intraperitoneal injection.    Once the tumors volume reached an average of 50–80 mm3, the mice were randomized into 4 groups (n=5), with either vehicle control (0.1% DMSO), lower dose of NC (8 mg/kg/week), or higher dose of NC (16  mg/kg/week) twice a day respectively.    As a positive control, mice were injected with DDP (8  mg/kg/week).    Te tumor volume (length×width×width) and body weight of the mice were monitored every 2 days.

来源文献：Yu F, Tan W, Chen Z, Shen X, Mo X, Mo X, He J, Deng Z, Wang J, Luo Z, Yang J. Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer.    Chin Med. 2022 Sep 29;17(1):115.    doi: 10.1186/s13020-022-00671-y.    PMID: 36175965;    PMCID: PMC9524076.

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标题:Insight into the structure, function and the tumor suppression effect of gasdermin E

成员:Yuge Long, Xiaoyuan Jia, Liang Chu

论文因子:5.3 发表期刊:BIOCHEMICAL PHARMACOLOGY pmid:38852642

【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】

标题:Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer

成员:Yu F; Tan W; Chen Z; Shen X; Mo X; Mo X; He J; Den

论文因子:4.546 发表期刊:Chin Med pmid:36175965

基本信息
CAS	No.13063-04-2
中文名称	氯化两面针碱
英文名称	Nitidine chloride
别名	氯化两面针碱;TSAHCl;光叶花椒碱
分子式	C21H18ClNO4
分子量	383.82
溶解性	Soluble in DMSO ≥0.1mg/mL(Need ultrasonic)
纯度	HPLC≥98%
外观(性状)	White to yellow Solid
储存条件	Powder: 2-8℃，2 years
EC	EINECS 683-192-4
MDL	MFCD01659688
SMILES	C[N+]1=CC2=CC(OC)=C(OC)C=C2C3=C1C4=CC5=C(OCO5)C=C4C=C3.[Cl-]
InChIKey	QLDAACVSUMUMOR-UHFFFAOYSA-M
InChI	InChI=1S/C21H18NO4.ClH/c1-22-10-13-7-17(23-2)18(24-3)8-15(13)14-5-4-12-6-19-20(26-11-25-19)9-16(12)21(14)22;/h4-10H,11H2,1-3H3;1H/q+1;/p-1
PubChem CID	25659
靶点	Others
通路	Others
背景说明	Nitidine chloride 是一种具有抗疟疾活性的化合物,可通过MAPK和NF-kB途径抑制Lps诱导的炎性细胞因子的产生。
单位	瓶