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- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
α-Ketoglutaric acid
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
328-50-7
- 规格：
1g/500mg/100mg/50mg
| 规格： | 1g | 产品价格： | ￥490.0 |
|---|---|---|---|
| 规格： | 500mg | 产品价格： | ￥390.0 |
| 规格： | 100mg | 产品价格： | ￥270.0 |
| 规格： | 50mg | 产品价格： | ￥200.0 |
是三羧酸循环的中间产物，同时通过转胺氨作用与谷氨酸和谷氨酰胺代谢联系起来。
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Mitochondria-Rich Microvesicles Alleviate CNI ED by Transferring Mitochondria and Suppressing Local Ferroptosis
成员:Zhenkang Liang, Zehong Chen, Chaowei Zhang, Cui Chen, Wende Yang, Yuxuan Zhang, Hongbo Wei
论文因子:6.6 发表期刊:International Journal of Nanomedicine pmid:39558916
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Multi-therapeutic-activity selenium nanodot toward preventing brain injury and restoring neurobehavioral functions following hemorrhagic stroke
成员:Zhang Yibin, Wang Xiaoyu, Niu Xuegang, Wang Haojie, Wu Yi, Li Chunwang, Wang Huimin, Lin Shen, Wang Dengliang, Lin Fuxin, Yao Peisen, Lin Yuanxiang, Kang Dezhi, Gao Bin
论文因子:10.6 发表期刊:JOURNAL OF NANOBIOTECHNOLOGY pmid:39272097
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Characterization of an aspartate aminotransferase encoded by YPO0623 with frequent nonsense mutations in Yersinia pestis
成员:Junyan Jin, Liting Xiao, Yarong Wu, Zhulin Sun, Ziyao Xiong, Yanbing Li, Yanting Zhao, Wenwu Yao, Leiming Shen, Yiming Cui, Yafang Tan, Yanping Han, Zongmin Du, Yujun Cui, Ruifu Yang, Kai Song, Yajun Song
论文因子:5.7 发表期刊:Frontiers in Cellular and Infection Microbiology pmid:38089818
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Expression Patterns and Functional Analysis of Three SmTAT Genes Encoding Tyrosine Aminotransferases in Salvia miltiorrhiza
成员:Shuai Dong, Long Wang, Huiting Qin, Hongbin Zhan, Donghao Wang, Xiaoyan Cao
论文因子:5.6 发表期刊:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES pmid:37958559
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:A chemo-biocatalyst based on glutamate oxidase-integrated biomimetic trimanganese tetraoxide as cascade composite nano-catalyst for synthesis of α Ketoglutaric acid
成员:Hongtong Hu, Yuyan Chang, Zhongjie Wang, Jiandong Cui, Shiru Jia, Yingjie Du
论文因子:9.9 发表期刊:JOURNAL OF COLLOID AND INTERFACE SCIENCE pmid:37515973
| 基本信息 | |
| CAS | No.328-50-7 |
| 中文名称 | α-酮戊二酸 |
| 英文名称 | α-Ketoglutaric acid |
| 别名 | 2-oxoglutaric acid;alpha-酮戊二酸;Alpha-Ketoglutaric acid |
| 分子式 | C5H6O5 |
| 分子量 | 146.1 |
| 溶解性 | Soluble in Water/DMSO ≥20mg/mL;Soluble in Ethanol ≥10mg/mL |
| 纯度 | HPLC≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 206-330-3 |
| MDL | MFCD00004165 |
| SMILES | OC(=O)CCC(=O)C(O)=O |
| InChIKey | KPGXRSRHYNQIFN-UHFFFAOYSA-N |
| InChI | InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10) |
| PubChem CID | 51 |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | 是三羧酸循环的中间产物,同时通过转胺氨作用与谷氨酸和谷氨酰胺代谢联系起来。 |
| 生物活性 | 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[1]. |
| In Vitro | 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) has other physiological capabilities including reduction of ammonia level formed in the lung and general ammonia detoxification， protective role against lipid peroxidation and neuroprotective effect against cyanide poisoning[1].2-Ketoglutaric acid acts as precursor for the synthesis of amino acids and nucleotides[2]. |
| 数据来源文献 | [1]. Huergo LF， et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35. [2]. Gou L， et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662. |
| 单位 | 瓶 |
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文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Mitochondria-Rich Microvesicles Alleviate CNI ED by Transferring Mitochondria and Suppressing Local Ferroptosis
成员:Zhenkang Liang, Zehong Chen, Chaowei Zhang, Cui Chen, Wende Yang, Yuxuan Zhang, Hongbo Wei
论文因子:6.6 发表期刊:International Journal of Nanomedicine pmid:39558916
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Multi-therapeutic-activity selenium nanodot toward preventing brain injury and restoring neurobehavioral functions following hemorrhagic stroke
成员:Zhang Yibin, Wang Xiaoyu, Niu Xuegang, Wang Haojie, Wu Yi, Li Chunwang, Wang Huimin, Lin Shen, Wang Dengliang, Lin Fuxin, Yao Peisen, Lin Yuanxiang, Kang Dezhi, Gao Bin
论文因子:10.6 发表期刊:JOURNAL OF NANOBIOTECHNOLOGY pmid:39272097
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Characterization of an aspartate aminotransferase encoded by YPO0623 with frequent nonsense mutations in Yersinia pestis
成员:Junyan Jin, Liting Xiao, Yarong Wu, Zhulin Sun, Ziyao Xiong, Yanbing Li, Yanting Zhao, Wenwu Yao, Leiming Shen, Yiming Cui, Yafang Tan, Yanping Han, Zongmin Du, Yujun Cui, Ruifu Yang, Kai Song, Yajun Song
论文因子:5.7 发表期刊:Frontiers in Cellular and Infection Microbiology pmid:38089818
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Expression Patterns and Functional Analysis of Three SmTAT Genes Encoding Tyrosine Aminotransferases in Salvia miltiorrhiza
成员:Shuai Dong, Long Wang, Huiting Qin, Hongbin Zhan, Donghao Wang, Xiaoyan Cao
论文因子:5.6 发表期刊:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES pmid:37958559
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:A chemo-biocatalyst based on glutamate oxidase-integrated biomimetic trimanganese tetraoxide as cascade composite nano-catalyst for synthesis of α Ketoglutaric acid
成员:Hongtong Hu, Yuyan Chang, Zhongjie Wang, Jiandong Cui, Shiru Jia, Yingjie Du
论文因子:9.9 发表期刊:JOURNAL OF COLLOID AND INTERFACE SCIENCE pmid:37515973
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