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- 技术资料
- 保存条件：
Powder:2-8℃,2 years
- 保质期：
Powder:2-8℃,2 years
- 英文名：
5-Hydroxy-1,4-naphthalenedione
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
481-39-0
- 规格：
25mg/10mg/5mg/100mg/50mg/20mg
| 规格： | 25mg | 产品价格： | ￥1016.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥612.0 |
| 规格： | 5mg | 产品价格： | ￥430.0 |
| 规格： | 100mg | 产品价格： | ￥1694.0 |
| 规格： | 50mg | 产品价格： | ￥1133.0 |
| 规格： | 20mg | 产品价格： | ￥572.0 |
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Ginkgo seed extract promotes longevity and stress resistance of Caenorhabditis elegans
成员:Nan Shen, Wen Zeng, Feng Leng, Jinkai Lu, Zhaogeng Lu, Jiawen Cui, Li Wang, Biao Jin
论文因子:5.396 发表期刊:Food & Function pmid:34812833
| 基本信息 | |
| CAS | No.481-39-0 |
| 中文名称 | 胡桃醌 |
| 英文名称 | 5-Hydroxy-1,4-naphthalenedione |
| 别名 | Regianin;5-羟基对萘醌;Juglone |
| 分子式 | C10H6O3 |
| 分子量 | 174.16 |
| 溶解性 | Soluble in DMSO/Ethanol(该产品在溶液状态不稳定，建议您现用现配) |
| 纯度 | GC≥97% |
| 外观(性状) | Orange to brown Solid |
| 储存条件 | Powder:2-8℃,2 years |
| EC | EINECS 207-567-5 |
| MDL | MFCD00001684 |
| SMILES | O=C(C1=C2C=CC=C1O)C=CC2=O |
| InChIKey | KQPYUDDGWXQXHS-UHFFFAOYSA-N |
| InChI | InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H |
| PubChem CID | 3806 |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | 5-Hydroxy-1,4-naphthalenedione是一种着色剂,具有抗菌活性。 |
| 生物活性 | Juglone (5-hydroxy-1，4-naphthoquinone) is yellow pigments found in black walnut (Juglans regia). Herbal preparations derived from black walnut have been used as hair dyes and skin colorants in addition to being applied topically for the treatment of acne， inflammatory diseases， ringworm， and fungal， bacterial， or viral infections.[1] |
| In Vitro | Exposure to juglone or plumbagin(1-20 microM)resulted in a concentration-dependent decrease in cell viability. The cytotoxicity of these quinones is due to two different mechanisms，namely，redox cycling and reaction with glutathione(GSH). Redox cycling results in the generation of the corresponding semiquinone radicals，which were detected by electron paramagnetic resonance. Incubation of keratinocytes with the quinones generated hydrogen peroxide(H(2)O(2))and resulted in the oxidation of GSH to GSSG. Depletion of GSH by buthionine sulfoximine enhanced semiquinone radical production，increased H(2)O(2)generation，and produced greater cytotoxicity，suggesting that GSH plays an important protective role. Both quinones decreased the intracellular levels of GSH. However，plumbagin stoichiometrically converted GSH to GSSG，indicating that redox cycling is its main metabolic pathway. In contrast，much of the GSH lost during juglone exposure，especially at the higher concentrations(10 and 20 microM)，did not appear as GSSG，suggesting that the cytotoxicity of this quinone may also involve nucleophilic addition to GSH.[1] |
| 数据来源文献 | [1]. J. Johnson Inbaraj， et al. Cytotoxic Action of Juglone and Plumbagin: A Mechanistic Study Using HaCaT Keratinocytes.Chem. Res. Toxicol. 2004， 17， 1， 55-62 |
| 单位 | 瓶 |
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文献和实验该产品被引用文献
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Ginkgo seed extract promotes longevity and stress resistance of Caenorhabditis elegans
成员:Nan Shen, Wen Zeng, Feng Leng, Jinkai Lu, Zhaogeng Lu, Jiawen Cui, Li Wang, Biao Jin
论文因子:5.396 发表期刊:Food & Function pmid:34812833
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IH0420 胡桃醌 抑制剂/拮抗剂/激动剂 索莱宝
￥430 - 1694
