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- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Fucoxanthin
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
3351-86-8
- 规格：
10mg/5mg/10mM*1mL in DMSO
| 规格： | 10mg | 产品价格： | ￥1286.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥752.0 |
| 规格： | 10mM*1mL in DMSO | 产品价格： | ￥1120.0 |
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Role of Fucoxanthin towards Cadmium-induced renal impairment with the antioxidant and anti-lipid peroxide activities
成员:Haoyue Yang, Ronge Xing, Song Liu, Huahua Yu, Pengcheng Li
论文因子:3.269 发表期刊:Bioengineered pmid:34569908
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Hyperaccumulation of fucoxanthin by enhancing methylerythritol phosphate pathway in Phaeodactylum tricornutum
成员:Hao Ting-Bin, Lu Yang, Zhang Zhong-Hong, Liu Si-Fen, Wang Xiang, Yang Wei-Dong, Balamurugan Srinivasan, Li Hong-Ye
论文因子:4.813 发表期刊:APPLIED MICROBIOLOGY AND BIOTECHNOLOGY pmid:34741642
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Effect of Fucoxanthin Administration on Thyroid Gland Injury Induced by Cadmium in Mice
成员:YangH;XingR;LiuS;LiP
论文因子:3.19 发表期刊:Biol Trace Elem Res pmid:32691210
| 基本信息 | |
| CAS | No.3351-86-8 |
| 中文名称 | 岩藻黄素 |
| 英文名称 | Fucoxanthin |
| 别名 | all-trans-Fucoxanthin |
| 分子式 | C42H58O6 |
| 分子量 | 658.91 |
| 溶解性 | Soluble in DMSO ≥10mg/mL |
| 纯度 | HPLC≥98% |
| 外观(性状) | Red to reddish brown Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-486-6 |
| MDL | MFCD01745140 |
| SMILES | O=C(/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C([H])=[C@@]=C([C@@]1(O)C)C(C)(C[C@H](OC(C)=O)C1)C)C[C@]2(C3(C)C)[C@@](C)(C[C@@H](O)C3)O2 |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | Fucoxanthin具有抗肥胖，抗糖尿病，抗氧化，抗炎，抗癌等多种生理活性。 |
| 生物活性 | Fucoxanthin (all-trans-Fucoxanthin) is a marine carotenoid and shows anti-obesity， anti-diabetic， anti-oxidant， anti-inflammatory and anticancer activities[1][2][3][4][5][6][7][8][9]. |
| In Vitro | The half maximal inhibitory concentration (IC50) of fucoxanthin against HeLa and SiHa cervical cancer cells was determined.Differentially expressed genes (DEGs) in SiHa cells treated with IC50 fucoxanthin were screened by high-throughput techniques and subjected to signal enrichment.HIST1H3D-knockdown models were created via transfection with a short hairpin HIST1H3D payload.Impacts on cell proliferation， cell-cycle distribution， colony formation， and apoptosis were studied.The fucoxanthin IC50 was 1 445 and 1 641 μM (Hela and SiHa cells， respectively).Chip results revealed 2 255 DEGs， including 943 upregulated and 1 312 downregulated genes， in fucoxanthin-treated versus untreated SiHa cells.Inhibition of HIST1H3D mRNA significantly reduced cell proliferation and colony formation， significantly augmented the percentage of apoptotic HeLa and SiHa cells， and cells were arrested in G0/G1 cell cycle phase.[5]Western Blot Analysis[8]：Cell Line:RAW 264.7 cells；Concentration:0-100 μg/mL；Incubation Time:24 h；Result: Inhibited LPS-induced iNOS and COX-2 protein expression in RAW 264.7 cells.Decreased NO and PEG2 concentrations in LPS-induced RAW 264.7 cells.RT-PCR[6]：Cell Line: Hela and SiHa cells；Concentration: 10 μg/mL；Incubation Time:4 h；Result: Down-regulated N-myc mRNA expression. |
| 细胞实验 | The results revealed that high doses of fucoxanthin administration significantly decreased BUN， KIM1， NGAL levels， increasing POD， SOD， CAT， and ascorbate APX levels.Fucoxanthin administration also promoted recovery of the renal functions， micro-structural organization， and ultra-structural organization in the renal cells.In summary， the ameliorative effects of fucoxanthin supplementation against cadmium-induced kidney damage were mediated via inhibiting oxidative stress and apoptosis， promoting the recovery of structural integrity of mitochondria.[9]Animal Model:6-week-old male and female Crl:CD (SD) rats， 6-week-old male and female ICR mice[3]Dosage: 10-2000 mg/kg/day for 28/30 days；Administration: p.o.；Result:No abnormal appearance or death occurred in the rats and ICR mice.Significantly increased the concentration of serum total cholesterol in rats and ICR mice.Animal Model: mice models subjected to cadmium-induced kidney damage， Six- to eight-week-old male Kunming mice (weight， 22–26 gram (g)/per mouse)[9]；Dosage:10-50 mg/kg/day for 14 days；Administration:p.o.；Result:Blocked the Cd-induced increase in the cadmium level.Significantly decreased the levels of blood urea nitrogen， creatinine and lipid peroxidation， and increased the levels of SOD， POD and reduced glutathione.Helped to restore mitochondrial structure and inhibit renal cell apoptosis. |
| 数据来源文献 | [1]. Gammone MA， et al. Anti-obesity activity of the marine carotenoid fucoxanthin. Mar Drugs. 2015 Apr 13;13(4):2196-214. [2]. Méresse S， Fodil M， Fleury F， Chénais B. Fucoxanthin， a Marine-Derived Carotenoid from Brown Seaweeds and Microalgae: A Promising Bioactive Compound for Cancer Therapy. Int J Mol Sci. 2020;21(23):9273. [3]. Yoshimi Niwano， et al. In Vivo and in Vitro Toxicity Studies of Fucoxanthin， a Marine Carotenoid. null. 2011;0 (0):319-328. [4]. ?udomová M， et al. A Microbiological， Toxicological， and Biochemical Study of the Effects of Fucoxanthin， a Marine Carotenoid， on Mycobacterium tuberculosis and the Enzymes Implicated in Its Cell Wall: A Link Between Mycobacterial Infection and Autoimmune Diseases. Mar Drugs. 2019 Nov 14;17(11):641. [5]. Ye G， et al. Fucoxanthin may inhibit cervical cancer cell proliferation via downregulation of HIST1H3D. J Int Med Res. 2020 Oct;48(10):300060520964011. [6]. Okuzumi J， et al. Inhibitory effects of fucoxanthin， a natural carotenoid， on N-myc expression and cell cycle progression in human malignant tumor cells. Cancer Lett. 1990 Nov 19;55(1):75-81. [7]. Ishikawa C， et al. Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product， fucoxanthinol. Int J Cancer. 2008 Dec 1;123(11):2702-12. [8]. Shiratori K， et al. Effects of fucoxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Exp Eye Res. 2005 Oct;81(4):422-8. [9]. Yang H， et al. Role of Fucoxanthin towards Cadmium-induced renal impairment with the antioxidant and anti-lipid peroxide activities. Bioengineered. 2021 Dec;12(1):7235-7247. |
| 单位 | 瓶 |
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文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Role of Fucoxanthin towards Cadmium-induced renal impairment with the antioxidant and anti-lipid peroxide activities
成员:Haoyue Yang, Ronge Xing, Song Liu, Huahua Yu, Pengcheng Li
论文因子:3.269 发表期刊:Bioengineered pmid:34569908
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Hyperaccumulation of fucoxanthin by enhancing methylerythritol phosphate pathway in Phaeodactylum tricornutum
成员:Hao Ting-Bin, Lu Yang, Zhang Zhong-Hong, Liu Si-Fen, Wang Xiang, Yang Wei-Dong, Balamurugan Srinivasan, Li Hong-Ye
论文因子:4.813 发表期刊:APPLIED MICROBIOLOGY AND BIOTECHNOLOGY pmid:34741642
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Effect of Fucoxanthin Administration on Thyroid Gland Injury Induced by Cadmium in Mice
成员:YangH;XingR;LiuS;LiP
论文因子:3.19 发表期刊:Biol Trace Elem Res pmid:32691210
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