IA1310 腺苷-5'-三磷酸 抑制剂/拮抗剂/激动剂 索

使用本产品的案例（仅供参考）

In Vitro

Cell（(HPDE6?C7; 1.25-40 mM ATP; 16h）

In brief, HPDE6?C7 cells (1x10⁵ cells/ml) were treated with various concentrations of ATP (40, 20, 10, 5, 2.5 and 1.25 mM) for 16 h after 24 h of culture in 96?well plates. Subsequently, 10 μl MTT solution(5 mg/ml) were added into each well followed by 4 h of incubation at 37?C. Finally, the formazan crystals were dissolved with 100 μl dimethyl sulfoxide (DMSO) and measured with a microplate reader at a wavelength of 490 nm.

来源文献：Zhang Q, Hu F, Guo F, Zhou Q, Xiang H, Shang D. Emodin attenuates adenosine triphosphate?induced pancreatic ductal cell injury in vitro via the inhibition of the P2X7/NLRP3 signaling pathway. Oncol Rep. 2019 Oct;42(4):1589-1597. doi: 10.3892/or.2019.7270. Epub 2019 Aug 8. PMID: 31524270.

【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】

标题:Overcoming Debye length limitations: Three-dimensional wrinkled graphene field-effect transistor for ultra-sensitive adenosine triphosphate detection

成员:Ding Yue; Li Chonghui; Tian Meng; Wang Jihua; Wang

论文因子:5.142 发表期刊:Frontiers of Physics pmid:37251534

【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】

标题:Mechanistic insights into severe pulmonary inflammation caused by silica stimulation: The role of macrophage pyroptosis

成员:Lin Zhang; Jiaqi Tian; Lan Ma; Shuyin Duan

论文因子:7.129 发表期刊:ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】

标题:Artificially designed routes for the conversion of starch to value-added mannosyl compounds through coupling in vitro and in vivo metabolic engineering strategies

成员:Tian C; Yang J; Li Y; Zhang T; Li J; Ren C; Men Y;

论文因子:8.4 发表期刊:Metab Eng pmid:32623008

【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】

标题:Emodin attenuates adenosine triphosphate induced pancreatic ductal cell injury in vitro via the inhibition of the P2X7/NLRP3 signaling pathway

成员:Zhang Q; Hu F; Guo F; Zhou Q; Xiang H; Shang D

论文因子:4.136 发表期刊:Oncol Rep pmid:31524270

【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】

标题:Artificially designed routes for the conversion of starch to value-added mannosyl compounds through coupling in vitro and in vivo metabolic engineering strategies

成员:Tian C; Yang J; Li Y; Zhang T; Li J; Ren C; Men Y;

论文因子:9.835 发表期刊:Metab Eng pmid:32623008

基本信息
CAS	No.56-65-5
中文名称	腺苷-5'-三磷酸
英文名称	Adenosine Triphosphate
别名	Triphosphoric acid adenosine ester;Triphosphaden;Atipi;Ara-ATP;5-三磷酸腺苷;ATP disodium salt hydrate;腺苷三磷酸;Adenosine 5-triphosphate
分子式	C10H16N5O13P3
分子量	507.18
溶解性	Soluble in Water ≥20mg/mL
纯度	HPLC≥98%
外观(性状)	White to off-white Solid
储存条件	Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
EC	EINECS 200-283-2
MDL	MFCD00150755
SMILES	O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3COP(O)(OP(OP(O)(O)=O)(O)=O)=O
InChIKey	ZKHQWZAMYRWXGA-KQYNXXCUSA-N
InChI	InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
PubChem CID	5957
靶点	Others
通路	Others
背景说明	ATP 是体内能量储存和代谢的重要物质,为代谢提供能量,同时在细胞中作为辅酶发挥作用。
In Vitro	ATP(100-300μM)抑制TNF-α的产生32±8％，并且在300μM时，LPS + PHA刺激的全血中TNF-α产生的减少为65±4％。在LPS + PHA刺激的全血中，ATP(100，300μM)分别使IL-10水平增加48±5％(p = 0.01)和62±7％。 ATP不会显著改变IL-6的产生。
数据来源文献	[1]. Swennen EL， et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8.
单位	瓶