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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 保质期:
12个月
- 英文名:
Recombinant human NP PA Protein with C-terminal human Fc tag
- 库存:
In Stock
- 供应商:
缔码生物(武汉)科技有限公司
- 规格:
10μg
| 产品类型 | ECD Proteins |
|---|---|
| 靶点 | NP PA |
| Uniprot ID | P01160 |
| 背景 | The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by RefSeq, Oct 2015] |
| 货期 | In Stock |
| 产品英文名称 | Recombinant human NP PA Protein with C-terminal human Fc tag |
| 分子结构 | NP PA(Asn26-Tyr151) hFc(Glu99-Ala330) |
| 分子量 | The protein has a predicted molecular mass of 39.8 kDa after removal of the signal peptide. |
| 纯度 | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| 无菌性 | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| 储存与运输 | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| 别名 | ANF; ANP; CDD; CDP; PND; ATFB6; ATRST2; CDD-ANF |
| 标签 | C-Human Fc tag |
| 有无偶联 | Unconjugated |
| 表达宿主 | HEK293 |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| 应用范围 | Research use only |
Figure 1. Human NP PA Protein, hFc Tag on SDS-PAGE under reducing condition.
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嵌台抗体和人源化抗体 免疫球蛋白 的空间结构呈Y型,由二条重链和二条轻链通过二硫键相互连接而构成。每条链可分为可变区(N端)和恒定区(C端),抗原的吸附位点在可变区,细胞毒素或其他功能因子的吸附位点在恒定区。每个可变区中有3个部分在氨基酸序列上高度变化,在三维结构上是处在臼折叠端头的松散结构(CDR),是抗原的结合位点,其余部分为CDR的支持结构(FR)。不同种属的CDR结构是保守的,这样就可以通过蛋白质工程对抗体进行改造。 鼠单克隆抗体被人免疫系统排斥
相关专题单克隆抗体 单克隆抗体问世以来,在临床诊断、治疗与预防等方面发挥了巨大的作用。但是常用的鼠源单克隆抗 体具有较强的免疫原性,在临床反复应用中会引起人抗鼠抗体(human anti -mouse antibody,HAMA)反应, 导致半衰期缩短,治疗效果减弱。鼠源抗体人源化是指利用DNA 重组技术和蛋白质工程技术,对抗体基 因进行重组,在保留鼠源抗体对抗原有效结合部位的同时,最大限度地降低非结合部位的鼠源性。这种通 过重组基因所表达
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