- ￥1490 - 4690
- Solarbio
- 北京
- ID3580
- 2025年07月23日
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- 详细信息
- 技术资料
- 保存条件：
Powder:-20℃，1 year;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，1 year;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Diphenylterazine
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
344940-63-2
- 规格：
10mg/5mg/1mg
| 规格： | 10mg | 产品价格： | ￥4690.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥2990.0 |
| 规格： | 1mg | 产品价格： | ￥1490.0 |
| 基本信息 | |
| CAS | No.344940-63-2 |
| 英文名称 | Diphenylterazine |
| 别名 | DTZ |
| 分子式 | C25H19N3O |
| 分子量 | 377.44 |
| 溶解性 | Soluble in DMSO |
| 纯度 | ≥98% |
| 外观(性状) | Solid |
| 储存条件 | Powder:-20℃，1 year;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL | MFCD31619283 |
| SMILES | C1=CC=C(C=C1)CC2=C(N3C=C(N=C(C3=N2)C4=CC=CC=C4)C5=CC=CC=C5)O |
| InChIKey | ZMJMWAVOTYOMRN-UHFFFAOYSA-N |
| InChI | InChI=1S/C25H19N3O/c29-25-21(16-18-10-4-1-5-11-18)27-24-23(20-14-8-3-9-15-20)26-22(17-28(24)25)19-12-6-2-7-13-19/h1-15，17，29H，16H2 |
| PubChem CID | 135439143 |
| 背景说明 | Diphenylterazine是一种腔肠素类似物和生物发光剂，Diphenylterazine本身仅产生很少的背景，从而形成极好的信噪比。 |
| 生物活性 | Diphenylterazine (DTZ) is a bioluminescence agent. Diphenylterazine alone yielded very little background， leading to excellent signal-to-background ratios[1]. |
| In Vitro | We use these scaffolds to design artificial luciferases that selectively catalyse the oxidative chemiluminescence of the synthetic luciferin substrates diphenylterazine3 and 2-deoxycoelenterazine. The designed active sites position an arginine guanidinium group adjacent to an anion that develops during the reaction in a binding pocket with high shape complementarity.For both luciferin substrates， we obtain designed luciferases with high selectivity; the most active of these is a small (13.9 kDa) and thermostable (with a melting temperature higher than 95 °C) Enzyme that has a catalytic efficiency on diphenylterazine (kcat/Km = 106 M-1 s-1) comparable to that of native luciferases， but a much higher substrate specificity.[2]。 |
| 细胞实验 | We compared our LumiLuc - 8pyDTZ pair with several benchmark reporters in a tumor xenograft mouse model. Our new pair， which does not need organic cosolvents for in vivo administration， surpasses other reporters by detecting early tumors.LumiScarlet - 8pyDTZ was comparable to Akaluc - AkaLumine， the brightest ATP - dependent luciferase - luciferin pair， for detecting cells in deep tissues of mice.[4]。 |
| 细胞实验 | BALB/c mice are used and transfected with cells expressing teLuc， Antares， Antares2 and FLuc by injecting cells into the tail vein of BALB/c mice. After the diminishing of the FLuc bioluminescence， 0.3 μmol Diphenylterazine or furimazine is intraperitoneally injected. Mice are imaged with a 1-min exposure per frame over a course of 20 min. The images are processed using the Fiji image analysis software and the frames with highest signals in individual experiments are used for comparison[1]. |
| 数据来源文献 | [1]. Yeh HW， et al. Red-shifted luciferase-luciferin pairs for enhanced bioluminescence imaging. Nat Methods. 2017 Oct;14(10):971-974. [2]. Yeh AH， et al. De novo design of luciferases using deep learning. Nature. 2023 Feb;614(7949):774-780. [3]. Practical Notes for teLuc-DTZ and Antares2-DTZ (updated 07/29/2019). [4]. Hsien-Wei Yeh， et al. ATP-Independent Bioluminescent Reporter Variants To Improve in Vivo Imaging. ACS Chem Biol. 2019 May 17;14(5):959-965. |
| 单位 | 瓶 |
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ID3580 Diphenylterazine 染料/探针 索莱宝
￥1490 - 4690
