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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
BN82002 hydrochloride
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
1049740-43-3
- 规格：
50mg/25mg/10mg/1mg/5mg
| 规格： | 50mg | 产品价格： | ￥3790.0 |
|---|---|---|---|
| 规格： | 25mg | 产品价格： | ￥2390.0 |
| 规格： | 10mg | 产品价格： | ￥1490.0 |
| 规格： | 1mg | 产品价格： | ￥490.0 |
| 规格： | 5mg | 产品价格： | ￥1090.0 |
| 基本信息 | |
| CAS | No.1049740-43-3 |
| 英文名称 | BN82002 hydrochloride |
| 分子式 | C19H26ClN3O4 |
| 分子量 | 395.88 |
| 溶解性 | Soluble in DMSO |
| 纯度 | ≥98% |
| 外观(性状) | Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| SMILES | CN(C)C1=CC(=C(C(=C1)OC)O)CN(C)CCC2=CC=C(C=C2)[N+](=O)[O-].Cl |
| InChIKey | FGPZRTQNJSSCAQ-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H25N3O4.ClH/c1-20(2)17-11-15(19(23)18(12-17)26-4)13-21(3)10-9-14-5-7-16(8-6-14)22(24)25;/h5-8，11-12，23H，9-10，13H2，1-4H3;1H |
| PubChem CID | 16078950 |
| 靶点 | CDC25 phosphatase |
| 通路 | Metabolic Enzyme&Protease |
| 背景说明 | 是 CDC25 phosphatase 家族的有效，选择性和不可逆的泛抑制剂。 |
| 生物活性 | BN82002 hydrochloride is a potent， selective and irreversible inhibitor of CDC25 phosphatase family. BN82002 hydrochloride inhibits CDC25A， CDC25B2， CDC25B3， CDC25C CDC25A， and 25C-cat with IC50 values of 2.4， 3.9， 6.3， 5.4， and 4.6 μM， respectively. BN82002 hydrochloride displays ~20-fold greater selectivity over CD45 tyrosine phosphatase[1]. |
| IC50 | IC50: 2.4 μM (CDC25A)， 3.9 μM (CDC25B2)， 6.3 μM (CDC25B3)， 5.4 μM (CDC25C)， 4.6 μM (CDC25C-cat)[1]. |
| In Vitro | The effect of BN82002 on cell proliferation is evaluated in vitro on several human tumor cell lines. Menadione， which has been reported to inhibit cell proliferation， is used as a control. All of the examined cell lines are sensitive to BN82002 and Menadione in a concentration-dependent manner in the low micromolar range. The most sensitive is the pancreatic cancer cell line MIA PaCa-2 with an IC50 of 7.2 μM， and the less sensitive cell line is the colon cancer HT-29 with an IC50 of 32.6 μM. The range of activity is very similar to the one observed with menadione (5-15 μM). It is also showed that 50 μM BN82002 is a concentration that fully inhibits cell proliferation， the cell cycle distribution is only modestly affected with a slight decrease in S phase and an increase in cells containing both a G1 and a G2 DNA content， suggesting that the cells treated with BN82002 are arrested at various stages of the cell cycle[1]. |
| 数据来源文献 | [1]. Brezak MC， et al. A novel synthetic inhibitor of CDC25 phosphatases: BN82002. Cancer Res. 2004 May 1;64(9):3320-5. |
| 单位 | 瓶 |
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