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- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Amantadine Hydrochloride
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- CAS号：
665-66-7
- 规格：
500mg
| CAS | 665-66-7 |
| 中文名称 | 盐酸金刚烷胺 |
| 英文名称 | Amantadine Hydrochloride |
| 别名 | CI-719;1-Adamantanamine hydrochloride;Symmetrel |
| 分子式 | C10H18ClN |
| 分子量 | 187.71 |
| 规格 | 500mg |
| 溶解性 | Soluble in Water/DMSO(Need ultrasonic) |
| 纯度 | ≥98% |
| 级别 | Cell Culture |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| 运输条件 | 冷藏运输 |
| EC | EINECS 211-560-2 |
| MDL | MFCD00074723 |
| SMILES | C1C2CC3CC1CC(C2)(C3)N.Cl |
| InChIKey | WOLHOYHSEKDWQH-UHFFFAOYSA-N |
| InChI | InChI=1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H，1-6，11H2;1H |
| PubChem CID | 64150 |
| Beilstein Number | 4198854 |
| 靶点 | Influenza Virus |
| 通路 | Anti-infection |
| 背景说明 | 是一种有效的抗甲型流感 (influenza A) 病毒的抗病毒化合物，对 NMDA、M2 等多种离子通道均有抑制作用，还具有抗正痘病毒 (orthopoxvirus)活性。 |
| 生物活性 | Amantadine Hydrochloride 是一种口服高效抗病毒药，对甲型流感病毒具有活性。Amantadine Hydrochloride 可抑制多种离子通道，如 NMDA 和 M2，还可抑制冠状病毒离子通道。还具有抗逆转录病毒和抗癌活性。可用于帕金森病、术后认知功能障碍（POCD）和 COVID-19 研究。[1-4] |
| In Vitro | Amantadine is an antiviral drug with activity against influenza A viruses，but not influenza B viruses.[1] In Vero E6 cells infected with SARS-CoV-2，amantadine inhibited SARS-CoV-2 replication in two separate experiments with IC50 concentrations between 83 and 119 μM.[2] Amantadine markedly inhibited the proliferation of HepG2 and SMMC 7721 cells. The levels of the cell cycle related genes and proteins(cyclin D1，cyclin E and CDK2)were reduced by amantadine，and apoptosis was significantly induced. Amantadine treatment also reduced Bcl 2 and increased the Bax protein and mRNA levels.[4] |
| In Vivo | Amantadine attenuated surgery-induced learning and memory impairment. The context-related freezing behavior in the fear conditioning test were attenuated by amantadine(25(14-90)，n = 15，P = 0.029 compared with surgery group at 1 day after the training sessions in Barnes maze)and intracerebroventricular GDNF. [3] |
| 动物实验 | Four-month old male Fischer 344 rats were subjected to right carotid exposure under intravenous anesthesia. Some rats received intraperitoneal injection of 25 mg/kg/day amantadine for 3 days with the first dose at 15 min before the surgery or intracerebroventricular injection of GDNF or an anti-GDNF antibody at the end of surgery.[3] |
| 数据来源文献 | [1]. Suzuki H，et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003 Sep;9(3):195-200. [2]. Fink K，et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 24;13(4):539. [3]. Zhang J，et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct;121(4):773-85. [4]. Lan Z，et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 2015 Sep;36(3):904-10. |
| 单位 | 瓶 |
| 表格1 | |*|1mg|5mg|10mg|$$|1mM|5.3274mL|26.6368mL|53.2737mL|$$|5mM|1.0655mL|5.3274mL|10.6547mL|$$|10mM|0.5327mL|2.6637mL|5.3274mL| |
Single Nanoparticle in a Silica Shell for Localized Cell Delivery and Radiotherapy
Author：
Olga A. Goryacheva, Pavel D. Strokin, Viktoriia A. Anikina, Elizaveta A. Zamyatina, Nikita N. Chukavin, Andrey M. Burov, Daria V. Tsyupka, Arseni V Ushakov, Nelli R. Popova
IF：
5.5000
Publish_to：
ACS Applied Nano Materials
PMID：
Single Nanoparticle in a Silica Shell for Localized Cell Delivery and Radiotherapy
Author：
Olga A. Goryacheva, Pavel D. Strokin, Viktoriia A. Anikina, Elizaveta A. Zamyatina, Nikita N. Chukavin, Andrey M. Burov, Daria V. Tsyupka, Arseni V Ushakov, Nelli R. Popova
IF：
5.5000
Publish_to：
ACS Applied Nano Materials
PMID：
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文献和实验相关实验
以上。儿童15kg以下20mg/次，3次/日；15～30kg为100mg/次，1次/日。 氟康唑（fluconazole）胶囊剂（或片剂）50、100、150mg/粒，每日1次，每次50或100mg，必要时150或300mg/日。注射剂100mg/50ml静滴，100～200mg/日。 氟胞嘧啶（flurocytosine）片剂，每片250mg、500mg，每日100～150mg/kg，分3～4次服，疗程自数周至数月。 盐酸金刚烷胺（amantadine
以上。儿童15kg以下20mg/次，3次/日；15～30kg为100mg/次，1次/日。 氟康唑（fluconazole）胶囊剂（或片剂）50、100、150mg/粒，每日1次，每次50或100mg，必要时150或300mg/日。注射剂100mg/50ml静滴，100～200mg/日。 氟胞嘧啶（flurocytosine）片剂，每片250mg、500mg，每日100～150mg/kg，分3～4次服，疗程自数周至数月。 盐酸金刚烷胺（amantadine
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盐酸金刚烷胺
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