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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
[Des-Arg9]-Bradykinin acetate
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
23827-91-0
- 规格：
25mg/10mg/5mg
| 规格： | 25mg | 产品价格： | ￥1890.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥870.0 |
| 规格： | 5mg | 产品价格： | ￥540.0 |
| 基本信息 | |
| CAS | No.23827-91-0 |
| 中文名称 | [Des-Arg9]-缓激肽醋酸盐 |
| 英文名称 | [Des-Arg9]-Bradykinin acetate |
| 分子式 | C46H65N11O12 |
| 分子量 | 964.07 |
| 溶解性 | Soluble in Water(Need ultrasonic) |
| 纯度 | ≥98% |
| 外观(性状) | Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| SMILES | CC(=O)O.C1CC(N(C1)C(=O)C2CCCN2C(=O)C(CCCN=C(N)N)N)C(=O)NCC(=O)NC(CC3=CC=CC=C3)C(=O)NC(CO)C(=O)N4CCCC4C(=O)NC(CC5=CC=CC=C5)C(=O)O |
| InChIKey | FLNJLMIOGWOIQM-NHJGMUSQSA-N |
| InChI | InChI=1S/C44H61N11O10.C2H4O2/c45-29(15-7-19-48-44(46)47)40(61)55-22-10-18-35(55)42(63)54-21-8-16-33(54)38(59)49-25-36(57)50-30(23-27-11-3-1-4-12-27)37(58)52-32(26-56)41(62)53-20-9-17-34(53)39(60)51-31(43(64)65)24-28-13-5-2-6-14-28;1-2(3)4/h1-6，11-14，29-35，56H，7-10，15-26，45H2，(H，49，59)(H，50，57)(H，51，60)(H，52，58)(H，64，65)(H4，46，47，48);1H3，(H，3，4)/t29-，30-，31-，32-，33-，34-，35-;/m0./s1 |
| PubChem CID | 134821694 |
| 靶点 | Bradykinin B1 receptor |
| 通路 | GPCR & G Protein |
| 背景说明 | [Des-Arg9]-Bradykinin acetate 是缓激肽 B1 受体 (Bradykinin B1 receptor) 激动剂。 |
| 生物活性 | [Des-Arg9]-Bradykinin acetate is a Bradykinin B1 receptor agonist that displays selectivity for B1 over B2 receptors.[1] |
| In Vitro | [Des-Arg9]-Bradykinin acetate is a Bradykinin(B1)receptor agonist. The B2 receptor mediates the action of bradykinin(BK)and lysyl-bradykinin(Lys-BK)，the first set of bioactive kinins formed in response to injury from kininogen precursors through the actions of plasma and tissue kallikreins，whereas the B1 receptor mediates the action of [Des-Arg9]-Bradykinin(des-Arg9-BK)and Lys-des-Arg Arg9-BK，the second set of bioactive kinins formed through the actions of carboxypeptidases on BK and Lys-BK，respectively[1]. |
| 数据来源文献 | [1]. Leeb-Lundberg LM， et al. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev. 2005 Mar;57(1):27-77. |
| 单位 | 瓶 |
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文献和实验Disulfide Conjugation of Peptides to Oligonucleotides and Their Analogs
Zatsepin, T.S., Turner, J.J., Oretskaya, T.S., and Gait, M.J. 2005. Conjugates of oligonucleotides and analogues with cell penetrating peptides as gene silencing agents. Curr. Pharm. Des. 11:3639‐3654
cells recognize not peptides but lipid or glycolipid antigens bound to nonclassical MHC class Ib molecules such as CD1 in both humans and mice (6 ).
. These proteins present intracellular-derived peptides to cytotoxic T cells (1 ) and are expressed in all nucleated cells. In contrast, the nonclassical class I genes encode molecules (class Ib molecules) that have only recently been defined and their functions
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