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- II1280
- 2025年07月23日
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- 详细信息
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Isradipine
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
75695-93-1
- 规格：
100mg/50mg/5mg/1mg/10mg
| 规格： | 100mg | 产品价格： | ￥3524.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥2036.0 |
| 规格： | 5mg | 产品价格： | ￥338.0 |
| 规格： | 1mg | 产品价格： | ￥164.0 |
| 规格： | 10mg | 产品价格： | ￥548.0 |
| 基本信息 | |
| CAS | No.75695-93-1 |
| 中文名称 | 伊拉地平 |
| 英文名称 | Isradipine |
| 别名 | PN 200-110 |
| 分子式 | C19H21N3O5 |
| 分子量 | 371.39 |
| 溶解性 | Soluble in DMSO |
| 纯度 | ≥98% |
| 外观(性状) | Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 630-420-5 |
| MDL | MFCD00153820 |
| SMILES | CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC=CC3=NON=C32)C(=O)OC |
| InChIKey | HMJIYCCIJYRONP-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9，16，20H，1-5H3 |
| PubChem CID | 3784 |
| 靶点 | Calcium Channel |
| 通路 | Membrane Transporter&Ion Channel;Neuronal Signaling |
| 背景说明 | Isradipine是一种L 型钙通道阻滞剂。 |
| 生物活性 | Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine， as a powerful peripheral vasodilator， is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease[1][2][3]. |
| IC50 | L-type calcium channel[1][2] |
| In Vitro | Isradipine has much higher (＞40 fold) affinity for Cav1.3 channels as well as good brain bioavailability. Isradipine has nearly equal potency at Cav1.2 and Cav1.3 channels[1]. |
| 细胞实验 | Isradipine (0.1~3 mg/kg; p.o.) makes sodium excretion increase in a dose-dependent manner[3].Isradipine pre-treatment reduces 6-hydroxydopamine induced neurotoxicity at the striatal level. Protective effect of isradipine at the striatal level is dose-dependent as shown from 6 mice. Isradipine pre-treatment increases the number of surviving SNc DA cells after 6-hydroxydopamine induced degeneration. Isradipine is capable of protecting striatal dopaminergic terminals and SNc dopaminergic cell bodies against a slow， progressive insult created by intrastriatal injection of 6-hydroxydopamine[1]. |
| 数据来源文献 | [1]. Ilijic E， et al. The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease. Neurobiol Dis. 2011;43(2):364-371. [2]. Campbell CA， et al. Effects of isradipine， an L-type calcium channel blocker on permanent and transient focal cerebral ischemia in spontaneously hypertensive rats. Exp Neurol. 1997;148(1):45-50. [3]. Hof RP， et al. Selective effects of PN 200-110 (isradipine) on the peripheral circulation and the heart. Am J Cardiol. 1987;59(3):30B-36B. |
| 单位 | 瓶 |
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II1280 伊拉地平 跨膜转运/离子通道 索莱宝
￥164 - 3524
