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- 文献和实验
- 技术资料
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Cytochalasin E
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
36011-19-5
- 规格：
1mg
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Effects of 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione on autophagy and the PI3K/AKT/mTOR signaling pathway in human cholangiocarcinoma QBC939 cells
成员:Yongfei He, Yanghong Li, Tianyi Liang, Shutian Mo, Yuan Liao, Zijun Chen, Shuqi Zhao, Qingfu Ran, Chuangye Han, Pham Thi Thai Hoa
论文因子:2.587 发表期刊:Journal of Gastrointestinal Oncology pmid:35837172
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Curcumin Protects Porcine Granulosa Cells and Mouse Ovary Against Reproductive Toxicity of Aflatoxin B1 via Pi3K/Akt Signaling Pathway
成员:Sihong Li, Rui Li, Jun Jiang, Lu Liu, Xiang Ma, Tao Wang, Lili Zhao, Weifen Li, Dong Niu
论文因子:7.6 发表期刊:ENVIRONMENTAL POLLUTION pmid:39477004
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:MiR-210 promotes bone formation in ovariectomized rats by regulating osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells through downregulation of EPHA2
成员:Ren Lijue, Zhu Xiaohui, Tan Jiuting, Lv Xiangyu, Wang Jiahui, Hua Fei
论文因子:2.6 发表期刊:Journal of Orthopaedic Surgery and Research pmid:37904187
| 基本信息 | |
| CAS | No.36011-19-5 |
| 中文名称 | 细胞松驰素E |
| 英文名称 | Cytochalasin E |
| 分子式 | C28H33NO7 |
| 分子量 | 495.56 |
| 溶解性 | Soluble in DMSO(Need ultrasonic) |
| 纯度 | ≥98% |
| 外观(性状) | Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 252-835-7 |
| MDL | MFCD00005178 |
| SMILES | CC1CC=CC2C3C(O3)(C(C4C2(C(=O)NC4CC5=CC=CC=C5)OC(=O)OC=CC(C1=O)(C)O)C)C |
| InChIKey | LAJXCUNOQSHRJO-ZYGJITOWSA-N |
| InChI | InChI=1S/C28H33NO7/c1-16-9-8-12-19-23-27(4，35-23)17(2)21-20(15-18-10-6-5-7-11-18)29-24(31)28(19，21)36-25(32)34-14-13-26(3，33)22(16)30/h5-8，10-14，16-17，19-21，23，33H，9，15H2，1-4H3，(H，29，31)/b12-8+，14-13+/t16-，17-，19-，20-，21-，23-，26+，27+，28+/m0/s1 |
| PubChem CID | 5458385 |
| 靶点 | Actin |
| 通路 | Cytoskeleton |
| 背景说明 | 是一种有效的肌动蛋白解聚剂，能结合肌动蛋白丝的倒刺端并盖住，以防止肌动蛋白伸长。 |
| 生物活性 | Cytochalasin E 是一种强效肌动蛋白解聚剂，也是一种含有环氧化物的曲霉衍生真菌代谢物，还能抑制血管生成和肿瘤生长。[1-2] |
| In Vitro | Lower concentrations of cytochalasin E preferentially inhibited BCE cell proliferation without disrupting actin stress fibers.[1] Cytochalasin E prominently inhibited the growth of A549 cells in a dose-dependent manner，and especially cytochalasin E could induce the up-regulation of autophagy-related protein(LC3-II)and SQSTM1/p62.[2] |
| 细胞实验 | In vivo，cytochalasin E inhibited angiogenesis induced by basic fibroblast growth factor by 40% to 50% in the mouse cornea assay and inhibited the growth of Lewis lung tumors by approximately 72%.[1] |
| 数据来源文献 | [1]. Udagawa T，et al. Cytochalasin E，an epoxide containing Aspergillus-derived fungal metabolite，inhibits angiogenesis and tumor growth. J Pharmacol Exp Ther. 2000 Aug;294(2):421-7. [2]. Takanezawa Y，et al. Variation in the activity of distinct cytochalasins as autophagy inhibitiors in human lung A549 cells. Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):641-647. |
| 单位 | 瓶 |
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文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Effects of 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione on autophagy and the PI3K/AKT/mTOR signaling pathway in human cholangiocarcinoma QBC939 cells
成员:Yongfei He, Yanghong Li, Tianyi Liang, Shutian Mo, Yuan Liao, Zijun Chen, Shuqi Zhao, Qingfu Ran, Chuangye Han, Pham Thi Thai Hoa
论文因子:2.587 发表期刊:Journal of Gastrointestinal Oncology pmid:35837172
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Curcumin Protects Porcine Granulosa Cells and Mouse Ovary Against Reproductive Toxicity of Aflatoxin B1 via Pi3K/Akt Signaling Pathway
成员:Sihong Li, Rui Li, Jun Jiang, Lu Liu, Xiang Ma, Tao Wang, Lili Zhao, Weifen Li, Dong Niu
论文因子:7.6 发表期刊:ENVIRONMENTAL POLLUTION pmid:39477004
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:MiR-210 promotes bone formation in ovariectomized rats by regulating osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells through downregulation of EPHA2
成员:Ren Lijue, Zhu Xiaohui, Tan Jiuting, Lv Xiangyu, Wang Jiahui, Hua Fei
论文因子:2.6 发表期刊:Journal of Orthopaedic Surgery and Research pmid:37904187
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