- ￥340 - 480
- Solarbio
- 北京
- IK0560
- 2025年07月23日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Ketorolac
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
74103-06-3
- 规格：
50mg/100mg
| 规格： | 50mg | 产品价格： | ￥340.0 |
|---|---|---|---|
| 规格： | 100mg | 产品价格： | ￥480.0 |
| 基本信息 | |
| CAS | No.74103-06-3 |
| 中文名称 | 酮咯酸 |
| 英文名称 | Ketorolac |
| 别名 | RS37619 |
| 分子式 | C15H13NO3 |
| 分子量 | 255.27 |
| 溶解性 | Soluble in Water/DMSO(Need ultrasonic) |
| 纯度 | ≥98% |
| 外观(性状) | Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00864281 |
| SMILES | C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O |
| InChIKey | OZWKMVRBQXNZKK-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7，11H，8-9H2，(H，18，19) |
| PubChem CID | 3826 |
| 靶点 | COX |
| 通路 | Immunology & Inflammation |
| 背景说明 | 是一种非甾体抗炎化合物，为非选择性的 COX 抑制剂。 |
| 生物活性 | Ketorolac 是一种非选择性 COX 抑制剂，对 COX-1 和 COX-2 的 IC50 值分别为20 nM 和 120 nM，是一种 DDX3 抑制剂，可用于癌症研究，也是一种非甾体抗炎药。[1-4] |
| IC50 | COX-1: 20nM(IC50);COX-2: 120nM(IC50)[1] |
| In Vitro | Ketorolac was six times more active against COX-1(IC(50)= 0.02 microM)than COX-2(IC(50)= 0.12 microM)while bromfenac was approximately 32 times more active against COX-2(IC(50)= 0.0066 microM)than COX-1(IC(50)= 0.210 microM).[1] The expression of DDX3 in human OSCC line(H357)and the half maximal growth inhibitory concentration(IC50)of Ketorolac salt in H357 cell line is 2.6 μM. Ketorolac salt also inhibited the ATP hydrolysis by directly interacting with DDX3.[4] |
| 细胞实验 | One eye was treated with 50 microL(+/-)ketorolac 0.4% twice: 2 hours and 1 hour before LPS，nearly complete inhibition of FITC-dextran leakage and PGE(2)production in the anterior chamber of treated eyes，and a 22.5% inhibition(not statistically significant)in the contralateral eyes of rabbits.[1] Ketorolac(4 mg/kg/day，p.o.; 2 weeks)had no detrimental effect in the volume fraction of bone trabeculae formed inside the alveolar socket.[2] Intrathecal pretreatment with 60 microg of ketorolac significantly reduced neuronal death of rats and improved hindlimb motor function，and the long-term survival was similar to that in the control group.[3] |
| 数据来源文献 | [1]. Waterbury LD，et alT. Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr Med Res Opin. 2006 Jun;22(6):1133-40. [2]. Fracon RN，et al. Treatment with paracetamol，ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats. J Appl Oral Sci. 2010 Dec;18(6):630-4. [3]. Hsieh YC，et al. Intrathecal ketorolac pretreatment reduced spinal cord ischemic injury in rats. Anesth Analg. 2005 Apr;100(4):1134-1139. [4]. Samal SK，et al. Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer. Sci Rep. 2015 Apr 28;5:9982. |
| 单位 | 瓶 |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
IK0560 酮咯酸 免疫学/炎症 索莱宝
￥340 - 480
